Sequential Release of Paclitaxel and Imatinib from Core–Shell Microparticles Prepared by Coaxial Electrospray for Vaginal Therapy of Cervical Cancer

Sequential Release of Paclitaxel and Imatinib from Core–Shell Microparticles Prepared by Coaxial Electrospray for Vaginal Therapy of Cervical Cancer

To optimize the anti-tumor efficacy of combination therapy with paclitaxel (PTX) and imatinib (IMN), we used coaxial electrospray to prepare sequential-release core–shell microparticles composed of a PTX-loaded sodium hyaluronate outer layer and an IMN-loaded PLGA core. The morphology, size distribu...

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Bibliographic Details
Main Authors: Zhepeng Liu, Haini Chen, Fengmei Lv, Jun Wang, Shoujin Zhao, Yijun Li, Xuexin Xue, Yu Liu, Gang Wei, Weiyue Lu
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:International Journal of Molecular Sciences
Subjects:
coaxial electrospray
core–shell microparticles
sequential release
cervical cancer
paclitaxel
imatinib
Online Access:https://www.mdpi.com/1422-0067/22/16/8760

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