Mandibular dysmorphology due to abnormal embryonic osteogenesis in FGFR2-related craniosynostosis mice

Mandibular dysmorphology due to abnormal embryonic osteogenesis in FGFR2-related craniosynostosis mice

One diagnostic feature of craniosynostosis syndromes is mandibular dysgenesis. Using three mouse models of Apert, Crouzon and Pfeiffer craniosynostosis syndromes, we investigated how embryonic development of the mandible is affected by fibroblast growth factor receptor 2 (Fgfr2) mutations. Quantitat...

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Bibliographic Details
Main Authors: Susan M. Motch Perrine, Meng Wu, Nicholas B. Stephens, Divya Kriti, Harm van Bakel, Ethylin Wang Jabs, Joan T. Richtsmeier
Format: Article
Language:English
Published: The Company of Biologists 2019-05-01
Series:Disease Models & Mechanisms
Subjects:
Apert syndrome
Crouzon syndrome
Pfeiffer syndrome
Osteoclast
Cartilage
Transcriptome
FGFR2
Online Access:http://dmm.biologists.org/content/12/5/dmm038513

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