Proanthocyanidins Produce Significant Attenuation of Doxorubicin-Induced Mutagenicity via Suppression of Oxidative Stress

This study has been initiated to determine whether proanthocyanidins can protect against doxorubicin-induced mutagenicity in mice and to elucidate the potential mechanism of this protection. Pretreatment of mice with proanthocyanidins (100 mg/kg/day, orally) for 7 days and simultaneously with doxoru...

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Bibliographic Details
Main Authors: Sabry M. Attia, Saleh A. Bakheet, Nouf M. Al-Rasheed
Format: Article
Language:English
Published: Hindawi Limited 2010-01-01
Series:Oxidative Medicine and Cellular Longevity
Online Access:http://dx.doi.org/10.4161/oxim.3.6.14418