The Right Partner in Crime: Unlocking the Potential of the Anti-EGFR Antibody Cetuximab via Combination With Natural Killer Cell Chartering Immunotherapeutic Strategies

The Right Partner in Crime: Unlocking the Potential of the Anti-EGFR Antibody Cetuximab via Combination With Natural Killer Cell Chartering Immunotherapeutic Strategies

Cetuximab has an established role in the treatment of patients with recurrent/metastatic colorectal cancer and head and neck squamous cell cancer (HNSCC). However, the long-term effectiveness of cetuximab has been limited by the development of acquired resistance, leading to tumor relapse. By contra...

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Bibliographic Details
Main Authors: Hasan Baysal, Ines De Pauw, Hannah Zaryouh, Marc Peeters, Jan Baptist Vermorken, Filip Lardon, Jorrit De Waele, An Wouters
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Immunology
Subjects:
cetuximab
epidermal growth factor receptor (EGFR)
natural killer cells (NK cells)
combination therapy
immunotherapy
antibody-mediated cellular cytotoxicity (ADCC)
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.737311/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.737311/full

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