Transcriptomics-Guided Personalized Prescription of Targeted Therapeutics for Metastatic ALK-Positive Lung Cancer Case Following Recurrence on ALK Inhibitors

Transcriptomics-Guided Personalized Prescription of Targeted Therapeutics for Metastatic ALK-Positive Lung Cancer Case Following Recurrence on ALK Inhibitors

Non-small cell lung carcinoma (NSCLC) is the major cause of cancer-associated mortality. Identification of rearrangements in anaplastic lymphoma kinase (ALK) gene is an effective instrument for more effective targeted therapy of NSCLC using ALK inhibitors dramatically raising progression-free surviv...

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Bibliographic Details
Main Authors: Elena Poddubskaya, Alexey Bondarenko, Alexander Boroda, Evgenia Zotova, Alex Glusker, Svetlana Sletina, Luidmila Makovskaia, Philipp Kopylov, Marina Sekacheva, Alexey Moisseev, Madina Baranova
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Oncology
Subjects:
NSCLC
ALK
transcriptomics
personalized oncology
gene expression
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.01026/full

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