| Summary: | <p>Abstract</p> <p>Background</p> <p>Essential oils are currently studied for the control of different disease vectors, because of their efficacy on targeted organisms. In the present investigation, the larvicidal potential of essential oil extracted from Indian borage (<it>Plectranthus amboinicus</it>) was studied against the African anthropophagic malaria vector mosquito, <it>Anopheles gambiae.</it> The larvae of <it>An. gambiae</it> s.s laboratory colony and <it>An. gambiae</it> s.l of wild populations were assayed and the larval mortality was observed at 12, 24 and 48 h after exposure period with the concentrations of 3.125, 6.25, 12.5, 25, 50 and 100 ppm.</p> <p>Findings</p> <p>Larval mortality rates of the essential oil was entirely time and dose dependent. The LC<sub>50</sub> values of the laboratory colony were 98.56 (after 12h) 55.20 (after 24 h) and 32.41 ppm (after 48 h) and the LC<sub>90</sub> values were 147.40 (after 12h), 99.09 (after 24 h) and 98.84 ppm (after 48 h). The LC<sub>50</sub> and LC<sub>90</sub> values of the wild population were 119.52, 179.85 (after 12h) 67.53, 107.60 (after 24 h) and 25.51, 111.17 ppm (after 48 h) respectively. The oil showed good larvicidal potential after 48 h of exposure period against <it>An. gambiae</it>. The essential oil of Indian borage is a renowned natural source of larvicides for the control of the African malaria vector mosquito, <it>An. gambiae</it>.</p> <p>Conclusion</p> <p>The larvicidal efficacy shown by plant extracts against <it>An. gambiae</it> should be tested in semi field and small scale trials for effective compounds to supplement the existing larval control tools.</p>
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