Functional analyses of human LUC7-like proteins involved in splicing regulation and myeloid neoplasms

Functional analyses of human LUC7-like proteins involved in splicing regulation and myeloid neoplasms

Summary: Vertebrates have evolved three paralogs, termed LUC7L, LUC7L2, and LUC7L3, of the essential yeast U1 small nuclear RNA (snRNA)-associated splicing factor Luc7p. We investigated the mechanistic and regulatory functions of these putative splicing factors, of which one (LUC7L2) is mutated or d...

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Bibliographic Details
Main Authors: Noah J. Daniels, Courtney E. Hershberger, Xiaorong Gu, Caroline Schueger, William M. DiPasquale, Jonathan Brick, Yogen Saunthararajah, Jaroslaw P. Maciejewski, Richard A. Padgett
Format: Article
Language:English
Published: Elsevier 2021-04-01
Series:Cell Reports
Subjects:
LUC7L
LUC7L2
LUC7L3
alternative splicing
5′ splice site
myeloid neoplasms
Online Access:http://www.sciencedirect.com/science/article/pii/S221112472100303X

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http://www.sciencedirect.com/science/article/pii/S221112472100303X

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