Metabolic perturbation of epigenome by inhibiting -adenosylhomocysteine hydrolase elicits senescence through DNA damage response in hepatoma cells

Metabolic perturbation of epigenome by inhibiting -adenosylhomocysteine hydrolase elicits senescence through DNA damage response in hepatoma cells

Cellular senescence is a key physiological barrier against tumor and represents an option for therapeutic intervention. One pivotal intracellular stimulus causing senescence is DNA damage response, while the senescence-associated heterochromatin in cancer limits the strength of the DNA damage respon...

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Bibliographic Details
Main Authors:	Guozhen Wu, Ning Wang, Ying Luo, Yanyan Zhang, Peng Wang, Zhengyan Zhu, Yingtang Gao, Zhi Du, Bin Yang
Format:	Article
Language:	English
Published:	IOS Press 2017-04-01
Series:	Tumor Biology
Online Access:	https://doi.org/10.1177/1010428317699117

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