Uric Acid as a Marker of Kidney Disease: Review of the Current Literature

Uric Acid as a Marker of Kidney Disease: Review of the Current Literature

Uric acid has been implicated in the pathophysiology of renal disease; however renal clearance makes a causal relationship difficult to prove. We examine the current literature to support a potential role of uric acid in the development of kidney disease and to determine the potential to use uric ac...

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Main Authors: Christin Giordano, Olga Karasik, Kelli King-Morris, Abdo Asmar
Format: Article
Language:English
Published: Hindawi Limited 2015-01-01
Series:Disease Markers
Online Access:http://dx.doi.org/10.1155/2015/382918
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spelling doaj-3d11991ab4954d288342f6052fdcb1e92020-11-25T01:00:37ZengHindawi LimitedDisease Markers0278-02401875-86302015-01-01201510.1155/2015/382918382918Uric Acid as a Marker of Kidney Disease: Review of the Current LiteratureChristin Giordano0Olga Karasik1Kelli King-Morris2Abdo Asmar3Department of Internal Medicine, University of Central Florida, College of Medicine, Orlando, FL 32827, USADepartment of Internal Medicine, University of Central Florida, College of Medicine, Orlando, FL 32827, USADepartment of Internal Medicine, University of Central Florida, College of Medicine, Orlando, FL 32827, USADepartment of Internal Medicine, University of Central Florida, College of Medicine, Orlando, FL 32827, USAUric acid has been implicated in the pathophysiology of renal disease; however renal clearance makes a causal relationship difficult to prove. We examine the current literature to support a potential role of uric acid in the development of kidney disease and to determine the potential to use uric acid as a marker for future renal decline. After review, we conclude that uric acid is definitively linked to the development of chronic kidney disease and can be a poor prognostic factor for the development of acute renal failure, as well. However, further human research is needed before predictive models utilizing uric acid can be developed and used in the clinical setting.http://dx.doi.org/10.1155/2015/382918
collection DOAJ
language English
format Article
sources DOAJ
author Christin Giordano
Olga Karasik
Kelli King-Morris
Abdo Asmar
spellingShingle Christin Giordano
Olga Karasik
Kelli King-Morris
Abdo Asmar
Uric Acid as a Marker of Kidney Disease: Review of the Current Literature
Disease Markers
author_facet Christin Giordano
Olga Karasik
Kelli King-Morris
Abdo Asmar
author_sort Christin Giordano
title Uric Acid as a Marker of Kidney Disease: Review of the Current Literature
title_short Uric Acid as a Marker of Kidney Disease: Review of the Current Literature
title_full Uric Acid as a Marker of Kidney Disease: Review of the Current Literature
title_fullStr Uric Acid as a Marker of Kidney Disease: Review of the Current Literature
title_full_unstemmed Uric Acid as a Marker of Kidney Disease: Review of the Current Literature
title_sort uric acid as a marker of kidney disease: review of the current literature
publisher Hindawi Limited
series Disease Markers
issn 0278-0240
1875-8630
publishDate 2015-01-01
description Uric acid has been implicated in the pathophysiology of renal disease; however renal clearance makes a causal relationship difficult to prove. We examine the current literature to support a potential role of uric acid in the development of kidney disease and to determine the potential to use uric acid as a marker for future renal decline. After review, we conclude that uric acid is definitively linked to the development of chronic kidney disease and can be a poor prognostic factor for the development of acute renal failure, as well. However, further human research is needed before predictive models utilizing uric acid can be developed and used in the clinical setting.
url http://dx.doi.org/10.1155/2015/382918
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AT olgakarasik uricacidasamarkerofkidneydiseasereviewofthecurrentliterature
AT kellikingmorris uricacidasamarkerofkidneydiseasereviewofthecurrentliterature
AT abdoasmar uricacidasamarkerofkidneydiseasereviewofthecurrentliterature
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