BDNF contributes to the development of neuropathic pain by induction of spinal long-term potentiation via SHP2 associated GluN2B-containing NMDA receptors activation in rats with spinal nerve ligation

BDNF contributes to the development of neuropathic pain by induction of spinal long-term potentiation via SHP2 associated GluN2B-containing NMDA receptors activation in rats with spinal nerve ligation

The pathogenic mechanisms underlying neuropathic pain still remain largely unknown. In this study, we investigated whether spinal BDNF contributes to dorsal horn LTP induction and neuropathic pain development by activation of GluN2B-NMDA receptors via Src homology-2 domain-containing protein tyrosin...

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Bibliographic Details
Main Authors: Xu Ding, Jie Cai, Song Li, Xiao-Dan Liu, You Wan, Guo-Gang Xing
Format: Article
Language:English
Published: Elsevier 2015-01-01
Series:Neurobiology of Disease
Subjects:
Brain-derived neurotrophic factor
SHP2
GluN2B-containing NMDA receptor
Long-term potentiation
Neuropathic pain
Spinal dorsal horn
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996114003386

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http://www.sciencedirect.com/science/article/pii/S0969996114003386

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