The Role of Necroptosis in Atherosclerotic Disease
It is now known that cells do not always die by apoptosis, but can also undergo a process known as programmed cell necrosis, or necroptosis. In a study recently published in Science Advances, investigators reported that this proinflammatory process is active in human atherosclerosis, may promote gro...
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Elsevier
2016-10-01
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| Series: | JACC: Basic to Translational Science |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452302X16301176 |
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doaj-3cefb623c7344e8dbcd9b55229ca42092020-11-25T01:57:55ZengElsevierJACC: Basic to Translational Science2452-302X2016-10-011654855010.1016/j.jacbts.2016.08.002The Role of Necroptosis in Atherosclerotic DiseaseNicholas J. Leeper, MDIt is now known that cells do not always die by apoptosis, but can also undergo a process known as programmed cell necrosis, or necroptosis. In a study recently published in Science Advances, investigators reported that this proinflammatory process is active in human atherosclerosis, may promote growth of the necrotic core, and may serve as a novel molecular imaging and translational therapeutic target. These findings represent a major step in our goal to reduce coronary disease and stroke.http://www.sciencedirect.com/science/article/pii/S2452302X16301176atherosclerosisefferocytosisnecroptosis |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Nicholas J. Leeper, MD |
| spellingShingle |
Nicholas J. Leeper, MD The Role of Necroptosis in Atherosclerotic Disease JACC: Basic to Translational Science atherosclerosis efferocytosis necroptosis |
| author_facet |
Nicholas J. Leeper, MD |
| author_sort |
Nicholas J. Leeper, MD |
| title |
The Role of Necroptosis in Atherosclerotic Disease |
| title_short |
The Role of Necroptosis in Atherosclerotic Disease |
| title_full |
The Role of Necroptosis in Atherosclerotic Disease |
| title_fullStr |
The Role of Necroptosis in Atherosclerotic Disease |
| title_full_unstemmed |
The Role of Necroptosis in Atherosclerotic Disease |
| title_sort |
role of necroptosis in atherosclerotic disease |
| publisher |
Elsevier |
| series |
JACC: Basic to Translational Science |
| issn |
2452-302X |
| publishDate |
2016-10-01 |
| description |
It is now known that cells do not always die by apoptosis, but can also undergo a process known as programmed cell necrosis, or necroptosis. In a study recently published in Science Advances, investigators reported that this proinflammatory process is active in human atherosclerosis, may promote growth of the necrotic core, and may serve as a novel molecular imaging and translational therapeutic target. These findings represent a major step in our goal to reduce coronary disease and stroke. |
| topic |
atherosclerosis efferocytosis necroptosis |
| url |
http://www.sciencedirect.com/science/article/pii/S2452302X16301176 |
| work_keys_str_mv |
AT nicholasjleepermd theroleofnecroptosisinatheroscleroticdisease AT nicholasjleepermd roleofnecroptosisinatheroscleroticdisease |
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