Synergistic apoptosis following endoplasmic reticulum stress aggravation in mucinous colon cancer

Synergistic apoptosis following endoplasmic reticulum stress aggravation in mucinous colon cancer

Abstract Background Mucinous colon cancers (MCC) are characterized by abundant production of mucin 2 (MUC2) protein and are less sensitive to standard systemic chemotherapy. We postulated that severe/persistent endoplasmic reticulum stress (ERS) aggravation in MCC would overwhelm compensatory cytopr...

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Bibliographic Details
Main Authors: Ashok K. Dilly, Brendon D. Honick, Yong J. Lee, David L. Bartlett, Haroon A. Choudry
Format: Article
Language:English
Published: BMC 2020-08-01
Series:Orphanet Journal of Rare Diseases
Subjects:
MUC2
Mucinous colon cancer
Xenograft
Colonoids
Endoplasmic reticulum stress
Online Access:http://link.springer.com/article/10.1186/s13023-020-01499-1

Internet

http://link.springer.com/article/10.1186/s13023-020-01499-1

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