The Combination of Single-Cell and Next-Generation Sequencing Can Reveal Mosaicism for <i>BRCA2</i> Mutations and the Fine Molecular Details of Tumorigenesis

The Combination of Single-Cell and Next-Generation Sequencing Can Reveal Mosaicism for <i>BRCA2</i> Mutations and the Fine Molecular Details of Tumorigenesis

Germline mutations in the <i>BRCA1</i> and <i>BRCA2</i> genes are responsible for hereditary breast and ovarian cancer syndrome. Germline and somatic <i>BRCA1/2</i> mutations may define therapeutic targets and refine cancer treatment options. However, routine BRCA...

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Bibliographic Details
Main Authors: Alexandra Gráf, Márton Zsolt Enyedi, Lajos Pintér, Éva Kriston-Pál, Gábor Jaksa, Árpád Bálind, Éva Ezer, Péter Horváth, Farkas Sükösd, Ernő Kiss, Lajos Haracska
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Cancers
Subjects:
<i>BRCA2</i>
laser microcapture microscopy
tumor sequencing
Online Access:https://www.mdpi.com/2072-6694/13/10/2354

Internet

https://www.mdpi.com/2072-6694/13/10/2354

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