Spectroscopic Properties of Two 5′-(4-Dimethylamino)Azobenzene Conjugated G-Quadruplex Forming Oligonucleotides

Spectroscopic Properties of Two 5′-(4-Dimethylamino)Azobenzene Conjugated G-Quadruplex Forming Oligonucleotides

The synthesis of two 5′-end (4-dimethylamino)azobenzene conjugated G-quadruplex forming aptamers, the thrombin binding aptamer (TBA) and the HIV-1 integrase aptamer (T30695), was performed. Their structural behavior was investigated by means of UV, CD, fluorescence spectroscopy, and gel electrophore...

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Bibliographic Details
Main Authors: Concetta Imperatore, Antonio Varriale, Elisa Rivieccio, Angela Pennacchio, Maria Staiano, Sabato D’Auria, Marcello Casertano, Carlo Altucci, Mohammadhassan Valadan, Manjot Singh, Marialuisa Menna, Michela Varra
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:International Journal of Molecular Sciences
Subjects:
G-quadruplexes
conjugated aptamers
CD G-quadruplexes
fluorescence G-quadruplexes
azobenzenes
trans-cis conversion
Online Access:https://www.mdpi.com/1422-0067/21/19/7103

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