New views of mildronate use for the prevention and correction of impairment of adaptive processes

• Main Author: L V Logunova
• Format: Article
• Language: English
• Published: Peoples’ Friendship University of Russia (RUDN University) 2009-03-01
• Series: RUDN Journal of Medicine
• Subjects: милдронат; эмоционально-болевой стресс; профилактика; коррекция; неферментные катионные; катехоламины
• Online Access: http://journals.rudn.ru/medicine/article/view/3772

Protective and normalizing mildronate action on the level of non enzyme kation proteins in the neurophils and contents of kateholamins in erythrocytes were revealed on the experimental model of the emotional-pain stress. The findings of numerous investigations demonstrate that positive effects of mildronate were connected not only with its metabolism-modifying action but with accumulated holinolike metabolites of karnitine and normalizing influence on the central parts of neuro-endocrine systems, which ensure its use with the aim of increasing of adaptation to the outer environmental factors as well at to the prolonged phycho-emotional overstrain.