Hot Spot Analysis of YAP-TEAD Protein-Protein Interaction Using the Fragment Molecular Orbital Method and Its Application for Inhibitor Discovery

Hot Spot Analysis of YAP-TEAD Protein-Protein Interaction Using the Fragment Molecular Orbital Method and Its Application for Inhibitor Discovery

The Hippo pathway is an important signaling pathway modulating growth control and cancer cell proliferation. Dysregulation of the Hippo pathway is a common feature of several types of cancer cells. The modulation of the interaction between yes-associated protein (YAP) and transcriptional enhancer as...

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Bibliographic Details
Main Authors: Jongwan Kim, Hocheol Lim, Sungho Moon, Seon Yeon Cho, Minhye Kim, Jae Hyung Park, Hyun Woo Park, Kyoung Tai No
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Cancers
Subjects:
protein-protein interaction
YAP-TEAD inhibitor
virtual screening
binding assays
fragment molecular orbital method
anticancer
Online Access:https://www.mdpi.com/2072-6694/13/16/4246

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