CRISPR/Cas9-mediated knockout of clinically relevant alloantigenes in human primary T cells

CRISPR/Cas9-mediated knockout of clinically relevant alloantigenes in human primary T cells

Abstract Background The ability of CRISPR/Cas9 to mutate any desired genomic locus is being increasingly explored in the emerging area of cancer immunotherapy. In this respect, current efforts are mostly focused on the use of autologous (i.e. patient-derived) T cells. The autologous approach, howeve...

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Bibliographic Details
Main Authors: Elahe Kamali, Fatemeh Rahbarizadeh, Zohreh Hojati, Morten Frödin
Format: Article
Language:English
Published: BMC 2021-01-01
Series:BMC Biotechnology
Subjects:
CRISPR/Cas9
Knockout
Genome editing
TCR
T cell
Online Access:https://doi.org/10.1186/s12896-020-00665-4

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