Genetic characterization of a unique neuroendocrine transdifferentiation prostate circulating tumor cell-derived eXplant model

Genetic characterization of a unique neuroendocrine transdifferentiation prostate circulating tumor cell-derived eXplant model

Better tumor models are needed for the neuroendocrine subtype of castration resistant prostate cancer (CRPC-NE). Here, the authors develop patient-derived model from circulating tumor cells of a CRPC-NE patient, and provide insights on the sequential acquisition of driver gene mutations promoting NE...

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Main Authors: Vincent Faugeroux, Emma Pailler, Marianne Oulhen, Olivier Deas, Laura Brulle-Soumare, Céline Hervieu, Virginie Marty, Kamelia Alexandrova, Kiki C. Andree, Nikolas H. Stoecklein, Dominique Tramalloni, Stefano Cairo, Maud NgoCamus, Claudio Nicotra, Leon W. M. M. Terstappen, Nicolo Manaresi, Valérie Lapierre, Karim Fizazi, Jean-Yves Scoazec, Yohann Loriot, Jean-Gabriel Judde, Françoise Farace
Format: Article
Language:English
Published: Nature Publishing Group 2020-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-15426-2
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spelling doaj-3ccca0e5b5dc46c78df201565348528a2021-05-11T08:04:01ZengNature Publishing GroupNature Communications2041-17232020-04-0111111610.1038/s41467-020-15426-2Genetic characterization of a unique neuroendocrine transdifferentiation prostate circulating tumor cell-derived eXplant modelVincent Faugeroux0Emma Pailler1Marianne Oulhen2Olivier Deas3Laura Brulle-Soumare4Céline Hervieu5Virginie Marty6Kamelia Alexandrova7Kiki C. Andree8Nikolas H. Stoecklein9Dominique Tramalloni10Stefano Cairo11Maud NgoCamus12Claudio Nicotra13Leon W. M. M. Terstappen14Nicolo Manaresi15Valérie Lapierre16Karim Fizazi17Jean-Yves Scoazec18Yohann Loriot19Jean-Gabriel Judde20Françoise Farace21INSERM, U981 “Identification of Molecular Predictors and new Targets for Cancer Treatment”INSERM, U981 “Identification of Molecular Predictors and new Targets for Cancer Treatment”Gustave Roussy, Université Paris-Saclay, “Circulating Tumor Cells” Translational Platform, CNRS UMS3655—INSERM US23 AMMICAXenTechXenTechINSERM, U981 “Identification of Molecular Predictors and new Targets for Cancer Treatment”Gustave Roussy, Université Paris-Saclay, Experimental and Translational Pathology Platform, CNRS UMS3655–INSERM US23 AMMICAGustave Roussy, Université Paris-Saclay, Department of Cell TherapyMedical Cell Biophysics Group, Technical Medical Centre, Faculty of Science and Technology, University of TwenteDepartment of General, Visceral and Pediatric Surgery, Medical Faculty, University Hospital of the Heinrich-Heine-University DüsseldorfGustave Roussy, Université Paris-Saclay, Department of Cell TherapyXenTechGustave Roussy, Université Paris-Saclay, Department of Cancer MedicineGustave Roussy, Université Paris-Saclay, Department of Cancer MedicineMedical Cell Biophysics Group, Technical Medical Centre, Faculty of Science and Technology, University of TwenteMenarini Silicon Biosystems S.p.AGustave Roussy, Université Paris-Saclay, Department of Cell TherapyINSERM, U981 “Identification of Molecular Predictors and new Targets for Cancer Treatment”Gustave Roussy, Université Paris-Saclay, Experimental and Translational Pathology Platform, CNRS UMS3655–INSERM US23 AMMICAGustave Roussy, Université Paris-Saclay, Department of Cancer MedicineXenTechINSERM, U981 “Identification of Molecular Predictors and new Targets for Cancer Treatment”Better tumor models are needed for the neuroendocrine subtype of castration resistant prostate cancer (CRPC-NE). Here, the authors develop patient-derived model from circulating tumor cells of a CRPC-NE patient, and provide insights on the sequential acquisition of driver gene mutations promoting NE transdifferentiation.https://doi.org/10.1038/s41467-020-15426-2
collection DOAJ
language English
format Article
sources DOAJ
author Vincent Faugeroux
Emma Pailler
Marianne Oulhen
Olivier Deas
Laura Brulle-Soumare
Céline Hervieu
Virginie Marty
Kamelia Alexandrova
Kiki C. Andree
Nikolas H. Stoecklein
Dominique Tramalloni
Stefano Cairo
Maud NgoCamus
Claudio Nicotra
Leon W. M. M. Terstappen
Nicolo Manaresi
Valérie Lapierre
Karim Fizazi
Jean-Yves Scoazec
Yohann Loriot
Jean-Gabriel Judde
Françoise Farace
spellingShingle Vincent Faugeroux
Emma Pailler
Marianne Oulhen
Olivier Deas
Laura Brulle-Soumare
Céline Hervieu
Virginie Marty
Kamelia Alexandrova
Kiki C. Andree
Nikolas H. Stoecklein
Dominique Tramalloni
Stefano Cairo
Maud NgoCamus
Claudio Nicotra
Leon W. M. M. Terstappen
Nicolo Manaresi
Valérie Lapierre
Karim Fizazi
Jean-Yves Scoazec
Yohann Loriot
Jean-Gabriel Judde
Françoise Farace
Genetic characterization of a unique neuroendocrine transdifferentiation prostate circulating tumor cell-derived eXplant model
Nature Communications
author_facet Vincent Faugeroux
Emma Pailler
Marianne Oulhen
Olivier Deas
Laura Brulle-Soumare
Céline Hervieu
Virginie Marty
Kamelia Alexandrova
Kiki C. Andree
Nikolas H. Stoecklein
Dominique Tramalloni
Stefano Cairo
Maud NgoCamus
Claudio Nicotra
Leon W. M. M. Terstappen
Nicolo Manaresi
Valérie Lapierre
Karim Fizazi
Jean-Yves Scoazec
Yohann Loriot
Jean-Gabriel Judde
Françoise Farace
author_sort Vincent Faugeroux
title Genetic characterization of a unique neuroendocrine transdifferentiation prostate circulating tumor cell-derived eXplant model
title_short Genetic characterization of a unique neuroendocrine transdifferentiation prostate circulating tumor cell-derived eXplant model
title_full Genetic characterization of a unique neuroendocrine transdifferentiation prostate circulating tumor cell-derived eXplant model
title_fullStr Genetic characterization of a unique neuroendocrine transdifferentiation prostate circulating tumor cell-derived eXplant model
title_full_unstemmed Genetic characterization of a unique neuroendocrine transdifferentiation prostate circulating tumor cell-derived eXplant model
title_sort genetic characterization of a unique neuroendocrine transdifferentiation prostate circulating tumor cell-derived explant model
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2020-04-01
description Better tumor models are needed for the neuroendocrine subtype of castration resistant prostate cancer (CRPC-NE). Here, the authors develop patient-derived model from circulating tumor cells of a CRPC-NE patient, and provide insights on the sequential acquisition of driver gene mutations promoting NE transdifferentiation.
url https://doi.org/10.1038/s41467-020-15426-2
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