Rapamycin reverses status epilepticus-induced memory deficits and dendritic damage.

Rapamycin reverses status epilepticus-induced memory deficits and dendritic damage.

Cognitive impairments are prominent sequelae of prolonged continuous seizures (status epilepticus; SE) in humans and animal models. While often associated with dendritic injury, the underlying mechanisms remain elusive. The mammalian target of rapamycin complex 1 (mTORC1) pathway is hyperactivated f...

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Bibliographic Details
Main Authors: Amy L Brewster, Joaquin N Lugo, Vinit V Patil, Wai L Lee, Yan Qian, Fabiola Vanegas, Anne E Anderson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3594232?pdf=render

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