The Dual Immunoregulatory function of Nlrp12 in T Cell-Mediated Immune Response: Lessons from Experimental Autoimmune Encephalomyelitis

The Dual Immunoregulatory function of Nlrp12 in T Cell-Mediated Immune Response: Lessons from Experimental Autoimmune Encephalomyelitis

Although the etiology of multiple sclerosis (MS) remains enigmatic, the role of T cells is unquestionably central in this pathology. Immune cells respond to pathogens and danger signals via pattern-recognition receptors (PRR). Several reports implicate Nlrp12, an intracellular PRR, in the developmen...

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Bibliographic Details
Main Authors: Marjan Gharagozloo, Shaimaa Mahmoud, Camille Simard, Tara M. Mahvelati, Abdelaziz Amrani, Denis Gris
Format: Article
Language:English
Published: MDPI AG 2018-08-01
Series:Cells
Subjects:
Nlrp12
CNS
inflammation
T cell
EAE
spontaneous EAE
TCR signaling
2D2
Online Access:http://www.mdpi.com/2073-4409/7/9/119

Internet

http://www.mdpi.com/2073-4409/7/9/119

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