A CACNA1A variant associated with trigeminal neuralgia alters the gating of Cav2.1 channels

A CACNA1A variant associated with trigeminal neuralgia alters the gating of Cav2.1 channels

Abstract A novel missense mutation in the CACNA1A gene that encodes the pore forming α1 subunit of the CaV2.1 voltage-gated calcium channel was identified in a patient with trigeminal neuralgia. This mutation leads to a substitution of proline 2455 by histidine (P2455H) in the distal C-terminus regi...

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Bibliographic Details
Main Authors: Eder Gambeta, Maria A. Gandini, Ivana A. Souza, Laurent Ferron, Gerald W. Zamponi
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Molecular Brain
Subjects:
P/Q channel
Calcium channel
Facial pain
Ion channel
Electrophysiology
Online Access:https://doi.org/10.1186/s13041-020-00725-y

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