Network Simulations Reveal Molecular Signatures of Vulnerability to Age-Dependent Stress and Tau Accumulation

Alzheimer’s disease (AD) is the leading cause of dementia and one of the most common causes of death worldwide. As an age-dependent multifactorial disease, the causative triggers of AD are rooted in spontaneous declines in cellular function and metabolic capacity with increases in protein stressors...

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Bibliographic Details
Main Authors: Timothy E. Hoffman, William H. Hanneman, Julie A. Moreno
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Molecular Biosciences
Subjects:
tau
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2020.590045/full