Andrade-Oliveira Salvianolic Acid B Modulates Caspase-1–Mediated Pyroptosis in Renal Ischemia-Reperfusion Injury via Nrf2 Pathway

Andrade-Oliveira Salvianolic Acid B Modulates Caspase-1–Mediated Pyroptosis in Renal Ischemia-Reperfusion Injury via Nrf2 Pathway

Acute kidney injury (AKI) is a serious disease characterized by a rapid decline in kidney function. Oxidative stress is the primary pathogenesis of AKI. Salvianolic acid B (SalB), a water-soluble compound extracted from Salvia miltiorrhiza, possesses a potent antioxidant activity. Here, we investiga...

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Bibliographic Details
Main Authors: Yu Pang, Pei-chun Zhang, Rui-rui Lu, Hong-lian Li, Ji-cheng Li, Hong-xin Fu, Yi-Wen Cao, Guo-xing Fang, Bi-hao Liu, Jun-biao Wu, Jiu-yao Zhou, Yuan Zhou
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Pharmacology
Subjects:
acute renal injury
Salvianolic acid B
pyroptosis
Nrf2/NLRP3 signaling pathway
NLRP3 inflammasome
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.541426/full

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