-Secretase Modulators: Can We Combine Potency with Safety?

-Secretase Modulators: Can We Combine Potency with Safety?

-Secretase modulation has been proposed as a potential disease modifying anti-Alzheimer’s approach. -Secretase modulators (GSMs) cause a product shift from the longer amyloid-beta (Aβ) peptide isoforms to shorter, more soluble, and less amyloidogenic isoforms, without inhibiting APP or Notch proteol...

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Bibliographic Details
Main Authors:	Harrie J. M. Gijsen, Marc Mercken
Format:	Article
Language:	English
Published:	Hindawi Limited 2012-01-01
Series:	International Journal of Alzheimer's Disease
Online Access:	http://dx.doi.org/10.1155/2012/295207

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