Highly chemoselective synthesis of hindered amides via cobalt-catalyzed intermolecular oxidative hydroamidation

Highly chemoselective synthesis of hindered amides via cobalt-catalyzed intermolecular oxidative hydroamidation

α-Tertiary amides are common in bioactive natural products and pharmaceuticals, but challenging to access by conventional methods. Here, the authors report a single-step approach toward α-tertiary amides via cobalt-catalyzed intermolecular oxidative hydroamidation of unactivated alkenes.

Bibliographic Details
Main Authors: Yun-Nian Yin, Rui-Qi Ding, Dong-Chen Ouyang, Qing Zhang, Rong Zhu
Format: Article
Language:English
Published: Nature Publishing Group 2021-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-22373-z
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spelling doaj-3c93a1ac7caf497db46b81975ce37d372021-05-09T11:12:29ZengNature Publishing GroupNature Communications2041-17232021-05-0112111010.1038/s41467-021-22373-zHighly chemoselective synthesis of hindered amides via cobalt-catalyzed intermolecular oxidative hydroamidationYun-Nian Yin0Rui-Qi Ding1Dong-Chen Ouyang2Qing Zhang3Rong Zhu4Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking UniversityBeijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking UniversityBeijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking UniversityBeijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking UniversityBeijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking Universityα-Tertiary amides are common in bioactive natural products and pharmaceuticals, but challenging to access by conventional methods. Here, the authors report a single-step approach toward α-tertiary amides via cobalt-catalyzed intermolecular oxidative hydroamidation of unactivated alkenes.https://doi.org/10.1038/s41467-021-22373-z
collection DOAJ
language English
format Article
sources DOAJ
author Yun-Nian Yin
Rui-Qi Ding
Dong-Chen Ouyang
Qing Zhang
Rong Zhu
spellingShingle Yun-Nian Yin
Rui-Qi Ding
Dong-Chen Ouyang
Qing Zhang
Rong Zhu
Highly chemoselective synthesis of hindered amides via cobalt-catalyzed intermolecular oxidative hydroamidation
Nature Communications
author_facet Yun-Nian Yin
Rui-Qi Ding
Dong-Chen Ouyang
Qing Zhang
Rong Zhu
author_sort Yun-Nian Yin
title Highly chemoselective synthesis of hindered amides via cobalt-catalyzed intermolecular oxidative hydroamidation
title_short Highly chemoselective synthesis of hindered amides via cobalt-catalyzed intermolecular oxidative hydroamidation
title_full Highly chemoselective synthesis of hindered amides via cobalt-catalyzed intermolecular oxidative hydroamidation
title_fullStr Highly chemoselective synthesis of hindered amides via cobalt-catalyzed intermolecular oxidative hydroamidation
title_full_unstemmed Highly chemoselective synthesis of hindered amides via cobalt-catalyzed intermolecular oxidative hydroamidation
title_sort highly chemoselective synthesis of hindered amides via cobalt-catalyzed intermolecular oxidative hydroamidation
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2021-05-01
description α-Tertiary amides are common in bioactive natural products and pharmaceuticals, but challenging to access by conventional methods. Here, the authors report a single-step approach toward α-tertiary amides via cobalt-catalyzed intermolecular oxidative hydroamidation of unactivated alkenes.
url https://doi.org/10.1038/s41467-021-22373-z
work_keys_str_mv AT yunnianyin highlychemoselectivesynthesisofhinderedamidesviacobaltcatalyzedintermolecularoxidativehydroamidation
AT ruiqiding highlychemoselectivesynthesisofhinderedamidesviacobaltcatalyzedintermolecularoxidativehydroamidation
AT dongchenouyang highlychemoselectivesynthesisofhinderedamidesviacobaltcatalyzedintermolecularoxidativehydroamidation
AT qingzhang highlychemoselectivesynthesisofhinderedamidesviacobaltcatalyzedintermolecularoxidativehydroamidation
AT rongzhu highlychemoselectivesynthesisofhinderedamidesviacobaltcatalyzedintermolecularoxidativehydroamidation
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