MEF2C silencing attenuates load-induced left ventricular hypertrophy by modulating mTOR/S6K pathway in mice.

MEF2C silencing attenuates load-induced left ventricular hypertrophy by modulating mTOR/S6K pathway in mice.

BACKGROUND:The activation of the members of the myocyte enhancer factor-2 family (MEF2A, B, C and D) of transcription factors promotes cardiac hypertrophy and failure. However, the role of its individual components in the pathogenesis of cardiac hypertrophy remains unclear. METHODOLOGY/PRINCIPAL FIN...

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Main Authors: Ana Helena M Pereira, Carolina F M Z Clemente, Alisson C Cardoso, Thais H Theizen, Silvana A Rocco, Carla C Judice, Maria Carolina Guido, Vinícius D B Pascoal, Iscia Lopes-Cendes, José Roberto M Souza, Kleber G Franchini
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-12-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2794538?pdf=render

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http://europepmc.org/articles/PMC2794538?pdf=render

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