Guanidine derivative inhibits C. albicans biofilm growth on denture liner without promote loss of materials’ resistance

To reduce the burden of denture stomatitis and oral candidiasis, an aqueous solution containing polyhexamethylene guanidine hydrochloride (PHMGH) was investigated as an antifungal disinfectant against the leading cause of these oral conditions, Candida albicans. The solutions formulated with concent...

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Main Authors:	Isadora Martini Garcia, Stéfani Becker Rodrigues, Maria Eduarda Rodrigues Gama, Vicente Castelo Branco Leitune, Mary Anne Melo, Fabrício Mezzomo Collares
Format:	Article
Language:	English
Published:	KeAi Communications Co., Ltd. 2020-06-01
Series:	Bioactive Materials
Subjects:	Dental materials Guanidine Antifungal agents Candidiasis Denture liner
Online Access:	http://www.sciencedirect.com/science/article/pii/S2452199X20300190

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spelling	doaj-3c86c402cb794b2193bdc0b122a358f82021-02-02T08:48:24ZengKeAi Communications Co., Ltd.Bioactive Materials2452-199X2020-06-0152228232Guanidine derivative inhibits C. albicans biofilm growth on denture liner without promote loss of materials’ resistanceIsadora Martini Garcia0Stéfani Becker Rodrigues1Maria Eduarda Rodrigues Gama2Vicente Castelo Branco Leitune3Mary Anne Melo4Fabrício Mezzomo Collares5Dental Materials Laboratory, Postgraduate Program in Dentistry, School of Dentistry, Federal University of Rio Grande Do Sul, Rua Ramiro Barcelos, 2492, Rio Branco, 90035-003, Porto Alegre, RS, BrazilDental Materials Laboratory, Postgraduate Program in Dentistry, School of Dentistry, Federal University of Rio Grande Do Sul, Rua Ramiro Barcelos, 2492, Rio Branco, 90035-003, Porto Alegre, RS, BrazilDental Materials Laboratory, Postgraduate Program in Dentistry, School of Dentistry, Federal University of Rio Grande Do Sul, Rua Ramiro Barcelos, 2492, Rio Branco, 90035-003, Porto Alegre, RS, BrazilDental Materials Laboratory, Postgraduate Program in Dentistry, School of Dentistry, Federal University of Rio Grande Do Sul, Rua Ramiro Barcelos, 2492, Rio Branco, 90035-003, Porto Alegre, RS, BrazilPh.D. Program in Biomedical Sciences, University of Maryland School of Dentistry, Baltimore, MD, 21201, USA; Operative Dentistry Division, General Dentistry Department University of Maryland School of Dentistry, Baltimore, MD, 21201, USADental Materials Laboratory, Postgraduate Program in Dentistry, School of Dentistry, Federal University of Rio Grande Do Sul, Rua Ramiro Barcelos, 2492, Rio Branco, 90035-003, Porto Alegre, RS, Brazil; Corresponding author.To reduce the burden of denture stomatitis and oral candidiasis, an aqueous solution containing polyhexamethylene guanidine hydrochloride (PHMGH) was investigated as an antifungal disinfectant against the leading cause of these oral conditions, Candida albicans. The solutions formulated with concentrations ranging from 0.125 to 0.50 wt% enabled increasing disinfection at the initial 5min-contact with 72h-mature candida biofilms formed on denture liner specimens. After 10 min-contact, the solution at lower concentration has reached total fungal elimination. The results also indicated that the denture liners preserved their mechanical property after the maximum contact time with the solution at the highest tested concentration. The PHMGH aqueous solutions at 0.125 wt% could be applied to promote interim denture liner disinfection without promoting the loss of materials’ mechanical property.http://www.sciencedirect.com/science/article/pii/S2452199X20300190Dental materialsGuanidineAntifungal agentsCandidiasisDenture liner
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Isadora Martini Garcia Stéfani Becker Rodrigues Maria Eduarda Rodrigues Gama Vicente Castelo Branco Leitune Mary Anne Melo Fabrício Mezzomo Collares
spellingShingle	Isadora Martini Garcia Stéfani Becker Rodrigues Maria Eduarda Rodrigues Gama Vicente Castelo Branco Leitune Mary Anne Melo Fabrício Mezzomo Collares Guanidine derivative inhibits C. albicans biofilm growth on denture liner without promote loss of materials’ resistance Bioactive Materials Dental materials Guanidine Antifungal agents Candidiasis Denture liner
author_facet	Isadora Martini Garcia Stéfani Becker Rodrigues Maria Eduarda Rodrigues Gama Vicente Castelo Branco Leitune Mary Anne Melo Fabrício Mezzomo Collares
author_sort	Isadora Martini Garcia
title	Guanidine derivative inhibits C. albicans biofilm growth on denture liner without promote loss of materials’ resistance
title_short	Guanidine derivative inhibits C. albicans biofilm growth on denture liner without promote loss of materials’ resistance
title_full	Guanidine derivative inhibits C. albicans biofilm growth on denture liner without promote loss of materials’ resistance
title_fullStr	Guanidine derivative inhibits C. albicans biofilm growth on denture liner without promote loss of materials’ resistance
title_full_unstemmed	Guanidine derivative inhibits C. albicans biofilm growth on denture liner without promote loss of materials’ resistance
title_sort	guanidine derivative inhibits c. albicans biofilm growth on denture liner without promote loss of materials’ resistance
publisher	KeAi Communications Co., Ltd.
series	Bioactive Materials
issn	2452-199X
publishDate	2020-06-01
description	To reduce the burden of denture stomatitis and oral candidiasis, an aqueous solution containing polyhexamethylene guanidine hydrochloride (PHMGH) was investigated as an antifungal disinfectant against the leading cause of these oral conditions, Candida albicans. The solutions formulated with concentrations ranging from 0.125 to 0.50 wt% enabled increasing disinfection at the initial 5min-contact with 72h-mature candida biofilms formed on denture liner specimens. After 10 min-contact, the solution at lower concentration has reached total fungal elimination. The results also indicated that the denture liners preserved their mechanical property after the maximum contact time with the solution at the highest tested concentration. The PHMGH aqueous solutions at 0.125 wt% could be applied to promote interim denture liner disinfection without promoting the loss of materials’ mechanical property.
topic	Dental materials Guanidine Antifungal agents Candidiasis Denture liner
url	http://www.sciencedirect.com/science/article/pii/S2452199X20300190
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Guanidine derivative inhibits C. albicans biofilm growth on denture liner without promote loss of materials’ resistance

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