Endoplasmic Reticulum Stress and Unfolded Protein Response in Breast Cancer: The Balance between Apoptosis and Autophagy and Its Role in Drug Resistance

Endoplasmic Reticulum Stress and Unfolded Protein Response in Breast Cancer: The Balance between Apoptosis and Autophagy and Its Role in Drug Resistance

The unfolded protein response (UPR) is a stress response activated by the accumulation of unfolded or misfolded proteins in the lumen of the endoplasmic reticulum (ER) and its uncontrolled activation is mechanistically responsible for several human pathologies, including metabolic, neurodegenerative...

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Bibliographic Details
Main Authors: Lorenza Sisinni, Michele Pietrafesa, Silvia Lepore, Francesca Maddalena, Valentina Condelli, Franca Esposito, Matteo Landriscina
Format: Article
Language:English
Published: MDPI AG 2019-02-01
Series:International Journal of Molecular Sciences
Subjects:
endoplasmic reticulum stress
unfolded protein response
breast cancer
apoptosis
autophagy
drug resistance
hormone therapy
Online Access:https://www.mdpi.com/1422-0067/20/4/857

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