The Feasibility of Studying Metabolites in PICU Multi-Organ Dysfunction Syndrome Patients over an 8-Day Course Using an Untargeted Approach

The Feasibility of Studying Metabolites in PICU Multi-Organ Dysfunction Syndrome Patients over an 8-Day Course Using an Untargeted Approach

Metabolites are generated from critical biological functions and metabolism. This pediatric study reviewed plasma metabolites in patients suffering from multi-organ dysfunction syndrome (MODS) in the pediatric intensive care unit (PICU) using an untargeted metabolomics approach. Patients meeting the...

Full description

Bibliographic Details
Main Authors:	Mara Leimanis-Laurens, Danny Gil, Andrew Kampfschulte, Claire Krohn, Elizabeth Prentice, Dominic Sanfilippo, Jeremy W. Prokop, Todd A. Lydic, Surender Rajasekaran
Format:	Article
Language:	English
Published:	MDPI AG 2021-02-01
Series:	Children
Subjects:	blood plasma extracorporeal membrane oxygenation metabolites multiple organ dysfunction syndrome pediatric intensive care unit liquid chromatography–mass spectrometry
Online Access:	https://www.mdpi.com/2227-9067/8/2/151

Similar Items

Pediatric Multi-Organ Dysfunction Syndrome: Analysis by an Untargeted “Shotgun” Lipidomic Approach Reveals Low-Abundance Plasma Phospholipids and Dynamic Recovery over 8-Day Period, a Single-Center Observational Study
by: Mara L. Leimanis-Laurens, et al.
Published: (2021-02-01)

Dietary Intake Influences Metabolites in Healthy Infants: A Scoping Review
by: Mara L. Leimanis Laurens, et al.
Published: (2020-07-01)

Hexosylceramides and Glycerophosphatidylcholine GPC(36:1) Increase in Multi-Organ Dysfunction Syndrome Patients with Pediatric Intensive Care Unit Admission over 8-Day Hospitalization
by: Mara Leimanis-Laurens, et al.
Published: (2021-04-01)

Untargeted NMR-Based Methodology in the Study of Fruit Metabolites
by: Anatoly Petrovich Sobolev, et al.
Published: (2015-03-01)

Untargeted metabolomic profiling of Sphagnum fallax reveals novel antimicrobial metabolites
by: Jane D. Fudyma, et al.
Published: (2019-11-01)

JUMPm: A Tool for Large-Scale Identification of Metabolites in Untargeted Metabolomics
by: Xusheng Wang, et al.
Published: (2020-05-01)

Metabolite Profiles of the Cerebrospinal Fluid in Neurosyphilis Patients Determined by Untargeted Metabolomics Analysis
by: Li-Li Liu, et al.
Published: (2019-02-01)

Untargeted metabolomic approach to study the serum metabolites in women with polycystic ovary syndrome
by: Ying Yu, et al.
Published: (2021-08-01)

Using an Untargeted Metabolomics Approach to Identify Salivary Metabolites in Women with Breast Cancer
by: Daniele Xavier Assad, et al.
Published: (2020-12-01)

Untargeted Metabolite Profiling for Screening Bioactive Compounds in Digestate of Manure under Anaerobic Digestion
by: Jiaxin Lu, et al.
Published: (2019-11-01)

Impact of Extracorporeal Detoxification on the Serum Levels of Microbial Aromatic Acid Metabolites in Sepsis
by: S. E. Khoroshilov, et al.
Published: (2015-10-01)

Untargeted metabolite profiling on the water-soluble metabolites of edible bird's nest through liquid chromatography-mass spectrometry
by: Shi-Ruo Tong, et al.
Published: (2020-02-01)

Untargeted Metabolomics Reveals Alterations in the Primary Metabolites and Potential Pathways in the Vegetative Growth of Morchella sextelata
by: Kejun Deng, et al.
Published: (2021-03-01)

Gene expression signatures identify paediatric patients with multiple organ dysfunction who require advanced life support in the intensive care unit
by: Rama Shankar, et al.
Published: (2020-12-01)

Metabolites change in Jatropha plants due to seed treatment with rhizobacteria and Rhizoctonia bataticola
by: Surender Kumar, et al.
Published: (2013-11-01)

Metabolites change in Jatropha plants due to seed treatment with rhizobacteria and Rhizoctonia bataticola
by: Surender Kumar, et al.
Published: (2013-12-01)

Untargeted LC-QTOF (ESI +) MS Analysis of Small Serum Metabolites Related to Prostate Cancer and Prostate Specific Antigen
by: Ramona Maria Maxim, et al.
Published: (2014-11-01)

Identification of Key Volatiles Differentiating Aromatic Rice Cultivars Using an Untargeted Metabolomics Approach
by: Yu Jie, et al.
Published: (2021-08-01)

Biological Filtering and Substrate Promiscuity Prediction for Annotating Untargeted Metabolomics
by: Neda Hassanpour, et al.
Published: (2020-04-01)

A New Paradigm for Known Metabolite Identification in Metabonomics/Metabolomics: Metabolite Identification Efficiency
by: Jeremy R. Everett
Published: (2015-01-01)

Metabolite profiling of defence-related secondary metabolites in tobacco cells, in response to ergosterol, a steroid from fungal membranes
by: Tugizimana, Fidele
Published: (2012)

Understanding Suicide in Our Community through the Lens of the Pediatric ICU: An Epidemiological Review (2011–2017) of One Midwestern City in the US
by: Andrew Kampfschulte, et al.
Published: (2021-01-01)

Untargeted serum metabolomics and tryptophan metabolism profiling in type 2 diabetic patients with diabetic glomerulopathy
by: Fanliang Zhang, et al.
Published: (2021-01-01)

Untargeted Metabolomics Reveals Major Differences in the Plasma Metabolome between Colorectal Cancer and Colorectal Adenomas
by: Tanja Gumpenberger, et al.
Published: (2021-02-01)

Common day-to-day questions in the PICU regarding invasive mechanical ventilation
by: Shekhar T Venkataraman
Published: (2014-01-01)

Investigating the Role of Tomato Phytochemicals through Targeted and Untargeted Metabolomics
by: Cichon, Morgan Julienne
Published: (2015)

Liquid chromatography metabolite profiling of tenofovir disoproxil fumarate
by: Kokil Sachin, et al.
Published: (2009-01-01)

Simultaneous untargeted and targeted metabolomics profiling of underivatized primary metabolites in sulfur-deficient barley by ultra-high performance liquid chromatography-quadrupole/time-of-flight mass spectrometry
by: Hikmat Ghosson, et al.
Published: (2018-07-01)

Application of in situ Solid-Phase Microextraction on Mediterranean Sponges for Untargeted Exometabolome Screening and Environmental Monitoring
by: Barbara Bojko, et al.
Published: (2019-10-01)

Metabolite signature during short-day induced growth cessation in Populus
by: Miyako eKusano, et al.
Published: (2011-07-01)

Untargeted Metabolomics Identifies Key Metabolic Pathways Altered by Thymoquinone in Leukemic Cancer Cells
by: Asma Ahmed AlGhamdi, et al.
Published: (2020-06-01)

Bridging Targeted and Untargeted Mass Spectrometry-Based Metabolomics via Hybrid Approaches
by: Li Chen, et al.
Published: (2020-08-01)

Insights into Tissue-specific Specialized Metabolism in Tieguanyin Tea Cultivar by Untargeted Metabolomics
by: Si Chen, et al.
Published: (2018-07-01)

Thyroid Hormone and Blood Metabolites Concentration of Gilts Superovulated Prior to Mating
by: RA Mege, et al.
Published: (2009-05-01)

Regulation of Gastrointestinal Immunity by Metabolites
by: Bon-Hee Gu, et al.
Published: (2021-01-01)

Left Atrial Decompression by Percutaneous Left Atrial Venting Cannula Insertion during Venoarterial Extracorporeal Membrane Oxygenation Support
by: Ha Eun Kim, et al.
Published: (2016-06-01)

Inter-Hospital Transportation of Patients on Extracorporeal Life Support: A Single Center Experience
by: Yang Hyun Cho, et al.
Published: (2014-05-01)

Extracorporeal Therapy in Dermatology
by: Sumit Sen, et al.
Published: (2021-01-01)

Pre-hospital extra-corporeal cardiopulmonary resuscitation
by: Ben Singer, et al.
Published: (2018-03-01)

Extracorporeal Cardiopulmonary Resuscitation in Children of Asia Pacific: A Retrospective Analysis of Extracorporeal Life Support Organization Registry
by: Gai-Ling Chen, et al.
Published: (2018-01-01)