Evaluation of models of Parkinson’s Disease

• Main Authors: Shail Adrian Jagmag, Naveen eTripathi, Sunil Dutt Shukla, Sankar eMaiti, Sukant eKhurana
• Format: Article
• Language: English
• Published: Frontiers Media S.A. 2016-01-01
• Series: Frontiers in Neuroscience
• Subjects: Cholinergic Fibers; Dopaminergic Neurons; Drosophila melanogaster; Lewy Bodies; Maneb; Mice
• Online Access: http://journal.frontiersin.org/Journal/10.3389/fnins.2015.00503/full

Parkinson’s disease is one of the most common neurodegenerative diseases. Animal models have contributed a large part to our understanding and therapeutics developed for treatment of PD. There are several more exhaustive reviews of literature that provide the initiated insights into the specific models; however a novel synthesis of the basic advantages and disadvantages of different models is much needed. Here we compare both neurotoxin based and genetic models while suggesting some novel avenues in PD modelling. We also highlight the problems faced and promises of all the mammalian models with the hope of providing a framework for comparison of various systems.