Syntheses, Characterization and Antimicrobial Evaluation of Some 1, 3, 5-Trisubustituted Pyrazole Derivatives

Syntheses, Characterization and Antimicrobial Evaluation of Some 1, 3, 5-Trisubustituted Pyrazole Derivatives

A series of 1, 3, 5-trisubustituted pyrazole derivatives were synthesized and screened for antimicrobial activity. The compounds (2j-o) were evaluated against two gram-positive and two gram-negative bacteria and one fungus, at concentrations of 10 µg/mL and 50 µg/mL. The compounds were founds to be...

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Main Authors: Vertika Gautam, Viney Chawla, Pankaj k. Sonar, Shailendra K. Saraf
Format: Article
Language:English
Published: Hindawi Limited 2010-01-01
Series:E-Journal of Chemistry
Online Access:http://dx.doi.org/10.1155/2010/947215
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spelling doaj-3c743511ee1c44fb855fe4473f2e316a2020-11-25T00:13:18ZengHindawi LimitedE-Journal of Chemistry0973-49452090-98102010-01-01741190119510.1155/2010/947215Syntheses, Characterization and Antimicrobial Evaluation of Some 1, 3, 5-Trisubustituted Pyrazole DerivativesVertika Gautam0Viney Chawla1Pankaj k. Sonar2Shailendra K. Saraf3Faculty of Pharmacy, Northern India Engineering College, Lucknow-227105, Uttar Pradesh, IndiaFaculty of Pharmacy, Northern India Engineering College, Lucknow-227105, Uttar Pradesh, IndiaFaculty of Pharmacy, Northern India Engineering College, Lucknow-227105, Uttar Pradesh, IndiaFaculty of Pharmacy, Northern India Engineering College, Lucknow-227105, Uttar Pradesh, IndiaA series of 1, 3, 5-trisubustituted pyrazole derivatives were synthesized and screened for antimicrobial activity. The compounds (2j-o) were evaluated against two gram-positive and two gram-negative bacteria and one fungus, at concentrations of 10 µg/mL and 50 µg/mL. The compounds were founds to be inactive against P. aeruginosa and A. niger but exhibited moderate activity against B. subtilis, E. coli and S. aureus. It can be concluded that the newly synthesized compounds possess promising antimicrobial activity.http://dx.doi.org/10.1155/2010/947215
collection DOAJ
language English
format Article
sources DOAJ
author Vertika Gautam
Viney Chawla
Pankaj k. Sonar
Shailendra K. Saraf
spellingShingle Vertika Gautam
Viney Chawla
Pankaj k. Sonar
Shailendra K. Saraf
Syntheses, Characterization and Antimicrobial Evaluation of Some 1, 3, 5-Trisubustituted Pyrazole Derivatives
E-Journal of Chemistry
author_facet Vertika Gautam
Viney Chawla
Pankaj k. Sonar
Shailendra K. Saraf
author_sort Vertika Gautam
title Syntheses, Characterization and Antimicrobial Evaluation of Some 1, 3, 5-Trisubustituted Pyrazole Derivatives
title_short Syntheses, Characterization and Antimicrobial Evaluation of Some 1, 3, 5-Trisubustituted Pyrazole Derivatives
title_full Syntheses, Characterization and Antimicrobial Evaluation of Some 1, 3, 5-Trisubustituted Pyrazole Derivatives
title_fullStr Syntheses, Characterization and Antimicrobial Evaluation of Some 1, 3, 5-Trisubustituted Pyrazole Derivatives
title_full_unstemmed Syntheses, Characterization and Antimicrobial Evaluation of Some 1, 3, 5-Trisubustituted Pyrazole Derivatives
title_sort syntheses, characterization and antimicrobial evaluation of some 1, 3, 5-trisubustituted pyrazole derivatives
publisher Hindawi Limited
series E-Journal of Chemistry
issn 0973-4945
2090-9810
publishDate 2010-01-01
description A series of 1, 3, 5-trisubustituted pyrazole derivatives were synthesized and screened for antimicrobial activity. The compounds (2j-o) were evaluated against two gram-positive and two gram-negative bacteria and one fungus, at concentrations of 10 µg/mL and 50 µg/mL. The compounds were founds to be inactive against P. aeruginosa and A. niger but exhibited moderate activity against B. subtilis, E. coli and S. aureus. It can be concluded that the newly synthesized compounds possess promising antimicrobial activity.
url http://dx.doi.org/10.1155/2010/947215
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AT pankajksonar synthesescharacterizationandantimicrobialevaluationofsome135trisubustitutedpyrazolederivatives
AT shailendraksaraf synthesescharacterizationandantimicrobialevaluationofsome135trisubustitutedpyrazolederivatives
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