Transcription-coupled genetic instability marks acute lymphoblastic leukemia structural variation hotspots

Transcription-coupled genetic instability marks acute lymphoblastic leukemia structural variation hotspots

Progression of malignancy to overt disease requires multiple genetic hits. Activation-induced deaminase (AID) can drive lymphomagenesis by generating off-target DNA breaks at loci that harbor highly active enhancers and display convergent transcription. The first active transcriptional profiles from...

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Bibliographic Details
Main Authors: Merja Heinäniemi, Tapio Vuorenmaa, Susanna Teppo, Minna U Kaikkonen, Maria Bouvy-Liivrand, Juha Mehtonen, Henri Niskanen, Vasilios Zachariadis, Saara Laukkanen, Thomas Liuksiala, Kaisa Teittinen, Olli Lohi
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-07-01
Series:eLife
Subjects:
genetic instability
leukemia
GRO-seq
transcription
signal feature analysis
Online Access:https://elifesciences.org/articles/13087

Internet

https://elifesciences.org/articles/13087

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