Convenient and Efficient Microwave-Assisted Synthesis of a Methyl Derivative of the Fused Indoloquinoline Alkaloid Cryptosanguinolentine

• Main Authors: Robert M. Gengan, Pitchai Pandian, Chandraprakash Kumarsamy, Palathurai S. Mohan
• Format: Article
• Language: English
• Published: MDPI AG 2010-04-01
• Series: Molecules
• Subjects: cryptosanguinolentine; microwave; phase transfer catalysis
• Online Access: http://www.mdpi.com/1420-3049/15/5/3171/
• ISSN: 1420-3049

An efficient synthesis of a methyl derivative of the indoloquinoline alkaloid cryptosanguinolentine based on microwave-assisted reactions is described. The microwave-assisted synthesis of an intermediate 4-hydroxy-2-methylquinoline yielded 86% of the desired product and other intermediates prepared yielded high % of products in shorter reaction times, under optimum conditions, as compared to traditional methods.