Investigation of a Potential Pharmacokinetic Interaction Between Nebivolol and Fluvoxamine in Healthy Volunteers

Purpose: To investigate whether fluvoxamine coadministration can influence the pharmacokinetic properties of nebivolol and its active hydroxylated metabolite (4-OH-nebivolol) and to assess the consequences of this potential pharmacokinetic interaction upon nebivolol pharmacodynamics. Methods: This...

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Bibliographic Details
Main Authors: Ana-Maria Gheldiu, Laurian Vlase, Adina Popa, Corina Briciu, Dana Muntean, Corina Bocsan, Anca Buzoianu, Marcela Achim, Ioan Tomuta, Ioana Todor, Maria Neag
Format: Article
Language:English
Published: Canadian Society for Pharmaceutical Sciences 2017-04-01
Series:Journal of Pharmacy & Pharmaceutical Sciences
Online Access:https://journals.library.ualberta.ca/jpps/index.php/JPPS/article/view/28287