Detection of the transforming <it>AKT1 </it>mutation E17K in non-small cell lung cancer by high resolution melting

Detection of the transforming <it>AKT1 </it>mutation E17K in non-small cell lung cancer by high resolution melting

<p>Abstract</p> <p>Background</p> <p>A recurrent somatic mutation, E17K, in the pleckstrin homology domain of the <it>AKT1 </it>gene, has been recently described in breast, colorectal, and ovarian cancers. AKT1 is a pivotal mediator of signalling pathways in...

Full description

Bibliographic Details
Main Authors:	Fox Stephen B, Mitchell Paul L, Solomon Benjamin, Do Hongdo, Dobrovic Alexander
Format:	Article
Language:	English
Published:	BMC 2008-05-01
Series:	BMC Research Notes
Online Access:	http://www.biomedcentral.com/1756-0500/1/14

Similar Items

Limited copy number - high resolution melting (LCN-HRM) enables the detection and identification by sequencing of low level mutations in cancer biopsies
by: Do Hongdo, et al.
Published: (2009-10-01)

High resolution melting analysis for rapid and sensitive <it>EGFR </it>and <it>KRAS </it>mutation detection in formalin fixed paraffin embedded biopsies
by: Fox Stephen B, et al.
Published: (2008-05-01)

Rapid detection of carriers with <it>BRCA1 </it>and <it>BRCA2 </it>mutations using high resolution melting analysis
by: Fox Stephen B, et al.
Published: (2008-02-01)

High resolution melting for mutation scanning of <it>TP53 </it>exons 5–8
by: Fox Stephen B, et al.
Published: (2007-08-01)

High resolution melting analysis for the rapid and sensitive detection of mutations in clinical samples: <it>KRAS </it>codon 12 and 13 mutations in non-small cell lung cancer
by: Thomas David M, et al.
Published: (2006-12-01)

Effect of AKT1 (p. E17K) Hotspot Mutation on Malignant Tumorigenesis and Prognosis
by: Ying Chen, et al.
Published: (2020-10-01)

Prediction of a highly deleterious mutation E17K in AKT-1 gene: An in silico approach
by: Imran Khan, et al.
Published: (2017-07-01)

Targeting AKT1-E17K and the PI3K/AKT Pathway with an Allosteric AKT Inhibitor, ARQ 092.
by: Yi Yu, et al.
Published: (2015-01-01)

Accurate detection of low prevalence AKT1 E17K mutation in tissue or plasma from advanced cancer patients.
by: Elza C de Bruin, et al.
Published: (2017-01-01)

Integrated mutation, copy number and expression profiling in resectable non-small cell lung cancer
by: Do Hongdo, et al.
Published: (2011-03-01)

Simplifying the detection of <it>MUTYH </it>mutations by high resolution melting analysis
by: López-Villar Isabel, et al.
Published: (2010-08-01)

Spectrum of mutations in MMAA identified by high resolution melting analysis
by: Dempsey Nunez, Laura
Published: (2012)

Spectrum of mutations in MMAB identified by high resolution melting analysis
by: Illson, Margaret
Published: (2012)

Development of Protein-Catalyzed Capture (PCC) Agents with Application to the Specific Targeting of the E17K Point Mutation of AKt1
by: Deyle, Kaycie Marie
Published: (2014)

Cancer associated E17K mutation causes rapid conformational drift in AKT1 pleckstrin homology (PH) domain.
by: Ambuj Kumar, et al.
Published: (2013-01-01)

Detection of somatic mutations by high-resolution DNA melting (HRM) analysis in multiple cancers.
by: Jesus Gonzalez-Bosquet, et al.
Published: (2011-01-01)

High Resolution Melting Analysis for Detecting p53 Gene Mutations in Patients with Non-small Cell Lung Cancer
by: Zhihong CHEN, et al.
Published: (2011-10-01)

Optimization of High Resolution Melting Analysis for Detection of KRAS Gene Mutations
by: Darbandy, Ashna
Published: (2010)

Detection of <it>NPM1 </it>exon 12 mutations and <it>FLT3 </it>– internal tandem duplications by high resolution melting analysis in normal karyotype acute myeloid leukemia
by: Carney Dennis A, et al.
Published: (2008-07-01)

A Fast, Sensitive and Accurate High Resolution Melting (HRM) Technology-Based Assay to Screen for Common K-ras Mutations
by: D. Kramer, et al.
Published: (2009-01-01)

Rapid screening of MMACHC gene mutations by high‐resolution melting curve analysis
by: Chao Wang, et al.
Published: (2020-06-01)

High Resolution Melt analysis for mutation screening in <it>PKD1 </it>and <it>PKD2 </it>
by: Fontes Michel, et al.
Published: (2011-10-01)

A comparison of Direct sequencing, Pyrosequencing, High resolution melting analysis, TheraScreen DxS, and the K-ras StripAssay for detecting <it>KRAS</it> mutations in non small cell lung carcinomas
by: Jancik Sylwia, et al.
Published: (2012-09-01)

High resolution melting analysis: a rapid and accurate method to detect CALR mutations.
by: Cristina Bilbao-Sieyro, et al.
Published: (2014-01-01)

FBXO17 promotes cell proliferation through activation of Akt in lung adenocarcinoma cells
by: Tomeka L. Suber, et al.
Published: (2018-10-01)

Inhibition of AKT1 signaling promotes invasion and metastasis of non-small cell lung cancer cells with K-RAS or EGFR mutations
by: Guanhua Rao, et al.
Published: (2017-08-01)

Rapid analysis of heterogeneously methylated DNA using digital methylation-sensitive high resolution melting: application to the <it>CDKN2B </it>(<it>p15</it>) gene
by: Candiloro Ida LM, et al.
Published: (2008-11-01)

Simultaneous mutation detection of three homoeologous genes in wheat by High Resolution Melting analysis and Mutation Surveyor<sup>®</sup>
by: Vincent Kate, et al.
Published: (2009-12-01)

Case Report and Literature Review: Pulmonary Sclerosing Pneumocytoma With Multiple Metastases Harboring AKT1 E17K Somatic Mutation and TP53 C176Y Germline Mutation
by: Qiushi Wang, et al.
Published: (2021-09-01)

A Panel of High Resolution Melting (HRM) Technology-Based Assays with Direct Sequencing Possibility for Effective Mutation Screening of EGFR and K-ras Genes
by: D. A. M. Heideman, et al.
Published: (2009-01-01)

High resolution melting analysis for the detection of EMS induced mutations in wheat <it>SbeIIa </it>genes
by: Botticella Ermelinda, et al.
Published: (2011-11-01)

Rapid screening for mutations associated with malignant hyperthermia using high-resolution melting curve analysis
by: I-Min Su, et al.
Published: (2021-01-01)

AKT1E¹⁷K Is Oncogenic in Mouse Lung and Cooperates with Chemical Carcinogens in Inducing Lung Cancer.
by: Donatella Malanga, et al.
Published: (2016-01-01)

Determining the effectiveness of High Resolution Melting analysis for SNP genotyping and mutation scanning at the <it>TP53 </it>locus
by: De Silva Deepika, et al.
Published: (2009-02-01)

Calreticulin mutation survey by high resolution melting method associated with unique presentations in essential thrombocythemic patients
by: Yi-Chang Liu, et al.
Published: (2020-04-01)

Detection of clinically silent alpha-globin gene mutations in Chinese using high resolution melting analysis
by: Ho, Sophia KW, et al.
Published: (2014)

A high-throughput protocol for mutation scanning of the <it>BRCA1 </it>and <it>BRCA2 </it>genes
by: Wong Stephen Q, et al.
Published: (2011-06-01)

The Study of PI3K/AKT Pathway in Lung Cancer Metastasis and Drug Resistance
by: Bingjing ZHU, et al.
Published: (2011-08-01)

Somatic mutation detection efficiency in EGFR: a comparison between high resolution melting analysis and Sanger sequencing
by: Reenu Anne Joy, et al.
Published: (2020-09-01)

Is high resolution melting analysis (HRMA) accurate for detection of human disease-associated mutations? A meta analysis.
by: Bing-Sheng Li, et al.
Published: (2011-01-01)