Detection of the transforming <it>AKT1 </it>mutation E17K in non-small cell lung cancer by high resolution melting

<p>Abstract</p> <p>Background</p> <p>A recurrent somatic mutation, E17K, in the pleckstrin homology domain of the <it>AKT1 </it>gene, has been recently described in breast, colorectal, and ovarian cancers. AKT1 is a pivotal mediator of signalling pathways in...

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Bibliographic Details
Main Authors: Fox Stephen B, Mitchell Paul L, Solomon Benjamin, Do Hongdo, Dobrovic Alexander
Format: Article
Language:English
Published: BMC 2008-05-01
Series:BMC Research Notes
Online Access:http://www.biomedcentral.com/1756-0500/1/14