Transmembrane but not soluble helices fold inside the ribosome tunnel
Integral membrane proteins are assembled into the ER membrane via the ribosome-translocon channel. Here authors use in vitro translation assays and MD simulations to show that folding in the ribosome is favorable for TM helices, but unfavorable for soluble helices.
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2018-12-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-07554-7 |