Sildenafil Inhibits Human Pulmonary Artery Smooth Muscle Cell Proliferation by Decreasing Capacitative Ca2+ Entry

Sildenafil Inhibits Human Pulmonary Artery Smooth Muscle Cell Proliferation by Decreasing Capacitative Ca2+ Entry

Ca2+ is a pivotal signal in human pulmonary artery smooth muscle cells (PASMCs) proliferation. Capacitative Ca2+ entry (CCE) via the store-operated channel (SOC), which encoded by the transient receptor potential (TRP) gene, is an important mechanism for regulating intracellular Ca2+ concentration (...

Full description

Bibliographic Details
Main Authors:	Cong Wang, Jun Wang, Lan Zhao, Yuexiu Wang, Jie Liu, Luping Shi, Meng Xu, Chen Wang
Format:	Article
Language:	English
Published:	Elsevier 2008-01-01
Series:	Journal of Pharmacological Sciences
Online Access:	http://www.sciencedirect.com/science/article/pii/S1347861319313763

Similar Items

Inhibition of SOC/Ca<sup>2+</sup>/NFAT pathway is involved in the anti-proliferative effect of sildenafil on pulmonary artery smooth muscle cells
by: Liu Jie, et al.
Published: (2009-12-01)

Regulation of capacitative and non-capacitative Ca2+ entry in A7r5 vascular smooth muscle cells
by: COLIN W TAYLOR, et al.
Published: (2004-01-01)

Ca2+ entry, efflux and release in smooth muscle
by: A MATTHEW, et al.
Published: (2004-01-01)

Pulmonary arterial hypertension - smooth muscle cell proliferation and perlecan
by: Tannenberg, Philip
Published: (2011)

Regulation of Ca2+ entry and Ca2+ efflux in smooth muscle cell lines
by: Broad, L. M.
Published: (1997)

Participation of PLK1 and FOXM1 in the hyperplastic proliferation of pulmonary artery smooth muscle cells in pulmonary arterial hypertension.
by: Jamie L Wilson, et al.
Published: (2019-01-01)

A study on blocking store-operated Ca2+ entry in pulmonary arterial smooth muscle cells with xyloketals from marine fungi
by: Zhou Jie-Bin, et al.
Published: (2017-12-01)

Adrenomedullin and adrenotensin regulate collagen synthesis and proliferation in pulmonary arterial smooth muscle cells
by: W. Li, et al.
Published: (2013-12-01)

Regulation of Ca²⁺-sensitive adenylyl cyclases by capacitative Ca²⁺ entry
by: Martin, Agnes C. L.
Published: (2008)

Calcineurin/NFAT Signaling Modulates Pulmonary Artery Smooth Muscle Cell Proliferation, Migration and Apoptosis in Monocrotaline-Induced Pulmonary Arterial Hypertension Rats
by: Rui-Lan He, et al.
Published: (2018-08-01)

Influence of the 15-HETE on cytosolic [ Ca2+] i of the rabbit pulmonary artery smooth muscle cells
by: Xiaobo Tang, et al.
Published: (2008-04-01)

Mir-206 regulates pulmonary artery smooth muscle cell proliferation and differentiation.
by: Samuel Jalali, et al.
Published: (2012-01-01)

The Role of Chloride Channels in Regulation of Pulmonary Artery Smooth Muscle Cell Proliferation
by: Liang, Wenbin
Published: (2012)

The Role of Chloride Channels in Regulation of Pulmonary Artery Smooth Muscle Cell Proliferation
by: Liang, Wenbin
Published: (2012)

Pulmonary Artery Smooth Muscle Cell Senescence Promotes the Proliferation of PASMCs by Paracrine IL-6 in Hypoxia-Induced Pulmonary Hypertension
by: Ai-Ping Wang, et al.
Published: (2021-04-01)

Sildenafil in pediatric pulmonary arterial hypertension
by: A K Dhariwal, et al.
Published: (2015-01-01)

Enhancer of zeste homolog 2 induces pulmonary artery smooth muscle cell proliferation.
by: Salman A Aljubran, et al.
Published: (2012-01-01)

Store operated calcium entry and TRPC channel expression in rat pulmonary artery smooth muscle cells
by: McElroy, Stuart Patrick
Published: (2006)

Regulation of Smooth Muscle Cell Proliferation by NADPH Oxidases in Pulmonary Hypertension
by: John C. Huetsch, et al.
Published: (2019-03-01)

Decreased expression of circ_0020397 in intracranial aneurysms may be contributing to decreased vascular smooth muscle cell proliferation via increased expression of miR-138 and subsequent decreased KDR expression
by: Yushe Wang, et al.
Published: (2019-01-01)

Correction: Enhancer of Zeste Homolog 2 Induces Pulmonary Artery Smooth Muscle Cell Proliferation
by: Salman A. Aljubran, et al.
Published: (2012-01-01)

Correction: Enhancer of Zeste Homolog 2 Induces Pulmonary Artery Smooth Muscle Cell Proliferation.
by: Salman A. Aljubran, et al.
Published: (2012-01-01)

CA²⁺-activated potassium channels in smooth muscle cell from cerebral artery of adult rat
by: Wang, Yihong
Published: (2008)

CA²⁺-activated potassium channels in smooth muscle cell from cerebral artery of adult rat
by: Wang, Yihong
Published: (2008)

Unique wreath-like smooth muscle proliferation of the pulmonary vasculature in pulmonary veno-occlusive disease versus pulmonary arterial hypertension
by: Ying-Ju Lai, et al.
Published: (2020-01-01)

Role of Macrophage Migration Inhibitory Factor in the Proliferation of Smooth Muscle Cell in Pulmonary Hypertension
by: Bo Zhang, et al.
Published: (2012-01-01)

Pri-microRNA-124 rs531564 polymorphism minor allele increases the risk of pulmonary artery hypertension by abnormally enhancing proliferation of pulmonary artery smooth muscle cells
by: Li Q, et al.
Published: (2017-05-01)

Krüppel-like Factor 5 contributes to pulmonary artery smooth muscle proliferation and resistance to apoptosis in human pulmonary arterial hypertension
by: Paulin Roxane, et al.
Published: (2011-09-01)

The role of thioredoxin and T-type Ca2+ channels in vascular smooth muscle cell proliferation
by: Johnson, Emily Louise
Published: (2016)

Nintedanib ameliorates experimental pulmonary arterial hypertension via inhibition of endothelial mesenchymal transition and smooth muscle cell proliferation.
by: Takeo Tsutsumi, et al.
Published: (2019-01-01)

Ubiquitin-specific protease 7 mediates platelet-derived growth factor-induced pulmonary arterial smooth muscle cells proliferation
by: Yanting Zhu, et al.
Published: (2021-09-01)

Chemerin Added to Endothelin-1 Promotes Rat Pulmonary Artery Smooth Muscle Cell Proliferation and Migration
by: Aliénor Hanthazi, et al.
Published: (2020-07-01)

Glycogen synthase kinase 3beta contributes to proliferation of arterial smooth muscle cells in pulmonary hypertension.
by: Piotr Sklepkiewicz, et al.
Published: (2011-04-01)

Role of NOX/ROS in 5-HT-mediated proliferation of rat pulmonary artery smooth muscle cells
by: ZHANG Ying, et al.
Published: (2020-12-01)

Inactivation of carboxyl terminus of Hsc70-interacting protein prevents hypoxia-induced pulmonary arterial smooth muscle cells proliferation by reducing intracellular Ca concentration
by: Fang Dong, et al.
Published: (2019-09-01)

Sildenafil in the treatment of pulmonary hypertension
by: O. S. Groznova, et al.
Published: (2016-03-01)

Sildenafil in the treatment of pulmonary hypertension
by: Christopher F Barnett, et al.
Published: (2006-12-01)

Baicalin Inhibits Hypoxia-Induced Pulmonary Artery Smooth Muscle Cell Proliferation via the AKT/HIF-1α/p27-Associated Pathway
by: Lin Zhang, et al.
Published: (2014-05-01)

Paeoniflorin inhibits pulmonary artery smooth muscle cells proliferation via upregulating A2B adenosine receptor in rat.
by: Guoqing Qian, et al.
Published: (2013-01-01)

Antiproliferative Effect of Echinacoside on Rat Pulmonary Artery Smooth Muscle Cells Under Hypoxia
by: Xiang-Yun Gai, et al.
Published: (2014-01-01)