Extended lifespan of bronchial epithelial cells maintains normal cellular phenotype and transcriptome integrity

Genetic studies have identified several epithelial-derived genes associated with airway diseases. However, techniques used to study gene function frequently exceed the proliferative potential of primary human bronchial epithelial cells (HBECs) isolated from patients. Increased expression of the poly...

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Bibliographic Details
Main Authors: Jonathan O'Loughlin, Robert J. Hall, Sangita Bhaker, Michael A. Portelli, Amanda Henry, Vincent Pang, David O. Bates, Tyson V. Sharp, Ian Sayers
Format: Article
Language:English
Published: European Respiratory Society 2021-01-01
Series:ERJ Open Research
Online Access:http://openres.ersjournals.com/content/7/1/00254-2020.full