Hepatitis E virus prevalence in Egyptian children with transfusion-dependent thalassemia
Hepatitis E virus (HEV) infection is one of the major public health problems in developing countries. HEV can cause chronic infections in immunocompromised individuals e.g. thalassemic patients with increased risk of morbidity and mortality. In addition there is possibility of HEV transmission throu...
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doaj-3c3bb9992a6f446e89959d5b35e985472020-11-25T02:58:34ZengElsevierBrazilian Journal of Infectious Diseases1413-86702019-01-012314044Hepatitis E virus prevalence in Egyptian children with transfusion-dependent thalassemiaDoaa Abdelmawla0Dalia Moemen1Ahmad Darwish2Wafaa Mowafy3Mansoura University, Faculty of Medicine, Department of Medical Microbiology and Immunology, Mansoura, EgyptMansoura University, Faculty of Medicine, Department of Medical Microbiology and Immunology, Mansoura, Egypt; Corresponding author.Mansoura University, Faculty of Medicine, Department of Pediatrics, Mansoura, EgyptMansoura University, Faculty of Medicine, Department of Medical Microbiology and Immunology, Mansoura, EgyptHepatitis E virus (HEV) infection is one of the major public health problems in developing countries. HEV can cause chronic infections in immunocompromised individuals e.g. thalassemic patients with increased risk of morbidity and mortality. In addition there is possibility of HEV transmission through blood transfusion. Therefore, the present study aimed to investigate the seroprevalence and risk factors of HEV infection in β-thalassemic children. Methods: This cross-sectional study was conducted on 140 Egyptian children suffering from β-thalassemia, attending the hematology outpatient clinic from April to October 2016. Serum samples from patients were collected and anti-HEV antibodies; Immunoglobulin G (IgG) and Immunoglobulin M (IgM)were measured by enzyme-linked immunosorbent assay (ELISA). Results: The seroprevalence of HEV in β-thalassemic chidren was relatively high (27.15%). Anti-HEV IgG prevalence was 24.29% while that of IgM was 2.86%. There was significant association between HEV infection and age, residence, liver enzymes and amount of blood transfusion per year. Conclusions: Thalasemic patients are vulnerable to chronicity and increased risk of morbidity and mortality from HEV infection. Frequent assessment of liver enzymes in thalassemic patients to monitor subclinical HEV is recommended. Close monitoring and HEV screening of blood donations should be taken in consideration. Public awareness about HEV endemicity, modes of transmission, and risk hazards especially in high risk group should be done to reduce the disease burden. Keywords: Hepatitis E virus (HEV), Prevalence, Thalassemia, Transfusionhttp://www.sciencedirect.com/science/article/pii/S1413867018306901 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Doaa Abdelmawla Dalia Moemen Ahmad Darwish Wafaa Mowafy |
spellingShingle |
Doaa Abdelmawla Dalia Moemen Ahmad Darwish Wafaa Mowafy Hepatitis E virus prevalence in Egyptian children with transfusion-dependent thalassemia Brazilian Journal of Infectious Diseases |
author_facet |
Doaa Abdelmawla Dalia Moemen Ahmad Darwish Wafaa Mowafy |
author_sort |
Doaa Abdelmawla |
title |
Hepatitis E virus prevalence in Egyptian children with transfusion-dependent thalassemia |
title_short |
Hepatitis E virus prevalence in Egyptian children with transfusion-dependent thalassemia |
title_full |
Hepatitis E virus prevalence in Egyptian children with transfusion-dependent thalassemia |
title_fullStr |
Hepatitis E virus prevalence in Egyptian children with transfusion-dependent thalassemia |
title_full_unstemmed |
Hepatitis E virus prevalence in Egyptian children with transfusion-dependent thalassemia |
title_sort |
hepatitis e virus prevalence in egyptian children with transfusion-dependent thalassemia |
publisher |
Elsevier |
series |
Brazilian Journal of Infectious Diseases |
issn |
1413-8670 |
publishDate |
2019-01-01 |
description |
Hepatitis E virus (HEV) infection is one of the major public health problems in developing countries. HEV can cause chronic infections in immunocompromised individuals e.g. thalassemic patients with increased risk of morbidity and mortality. In addition there is possibility of HEV transmission through blood transfusion. Therefore, the present study aimed to investigate the seroprevalence and risk factors of HEV infection in β-thalassemic children. Methods: This cross-sectional study was conducted on 140 Egyptian children suffering from β-thalassemia, attending the hematology outpatient clinic from April to October 2016. Serum samples from patients were collected and anti-HEV antibodies; Immunoglobulin G (IgG) and Immunoglobulin M (IgM)were measured by enzyme-linked immunosorbent assay (ELISA). Results: The seroprevalence of HEV in β-thalassemic chidren was relatively high (27.15%). Anti-HEV IgG prevalence was 24.29% while that of IgM was 2.86%. There was significant association between HEV infection and age, residence, liver enzymes and amount of blood transfusion per year. Conclusions: Thalasemic patients are vulnerable to chronicity and increased risk of morbidity and mortality from HEV infection. Frequent assessment of liver enzymes in thalassemic patients to monitor subclinical HEV is recommended. Close monitoring and HEV screening of blood donations should be taken in consideration. Public awareness about HEV endemicity, modes of transmission, and risk hazards especially in high risk group should be done to reduce the disease burden. Keywords: Hepatitis E virus (HEV), Prevalence, Thalassemia, Transfusion |
url |
http://www.sciencedirect.com/science/article/pii/S1413867018306901 |
work_keys_str_mv |
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