Loss of the osteogenic differentiation potential during senescence is limited to bone progenitor cells and is dependent on p53.

Loss of the osteogenic differentiation potential during senescence is limited to bone progenitor cells and is dependent on p53.

DNA damage can lead to the induction of cellular senescence. In particular, we showed that exposure to ionizing radiation (IR) leads to the senescence of bone marrow-derived multipotent stromal cells (MSC) and osteoblast-like stromal cells (OB-SC), a phenotype associated with bone loss. The mechanis...

Full description

Bibliographic Details
Main Authors: Geneviève Despars, Cynthia L Carbonneau, Pascal Bardeau, Daniel L Coutu, Christian M Beauséjour
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3756945?pdf=render

Similar Items

Similar Items