Pharmacological modulation of AMPA receptors rescues specific impairments in social behavior associated with the A350V Iqsec2 mutation

Pharmacological modulation of AMPA receptors rescues specific impairments in social behavior associated with the A350V Iqsec2 mutation

Abstract In this study we tested the hypothesis that pharmacological modulation of glutamatergic neurotransmission could rescue behavioral deficits exhibited by mice carrying a specific mutation in the Iqsec2 gene. The IQSEC2 protein plays a key role in glutamatergic synapses and mutations in the IQ...

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Bibliographic Details
Main Authors: Renad Jabarin, Nina Levy, Yasmin Abergel, Joshua H. Berman, Amir Zag, Shai Netser, Andrew P. Levy, Shlomo Wagner
Format: Article
Language:English
Published: Nature Publishing Group 2021-04-01
Series:Translational Psychiatry
Online Access:https://doi.org/10.1038/s41398-021-01347-1

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