A Case Report of Central Nervous System Graft-Versus-Host Disease and Literature Review

A Case Report of Central Nervous System Graft-Versus-Host Disease and Literature Review

As an adverse immune phenomenon, graft-versus-host disease often occurs after allogeneic hematopoietic stem cell transplantation. The incidence of acute and chronic graft-versus-host disease is about 40–60% and the mortality rate can reach 15%, which is a potentially fatal disease. There are rare Gv...

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Main Authors: Mingming Li, Yue Zhang, Yujia Guan, Zunwei Zhang, Hanbing Dong, Yang Zhao, Hui Deng
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Neurology
Subjects:
graft-versus-host disease
central nervous system
diffuse white matter lesions
immunosuppression
bone marrow transplantation
Online Access:https://www.frontiersin.org/articles/10.3389/fneur.2021.621392/full
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spelling doaj-3c32f787827b497e8bbacf49245eaf482021-03-10T05:20:47ZengFrontiers Media S.A.Frontiers in Neurology1664-22952021-03-011210.3389/fneur.2021.621392621392A Case Report of Central Nervous System Graft-Versus-Host Disease and Literature ReviewMingming LiYue ZhangYujia GuanZunwei ZhangHanbing DongYang ZhaoHui DengAs an adverse immune phenomenon, graft-versus-host disease often occurs after allogeneic hematopoietic stem cell transplantation. The incidence of acute and chronic graft-versus-host disease is about 40–60% and the mortality rate can reach 15%, which is a potentially fatal disease. There are rare GvHD cases involving the central nervous system. We reported a rare case of diffuse white matter changes after haploid bone marrow transplantation, summarizing its clinical manifestations and diagnosis and treatment in conjunction with the literature.https://www.frontiersin.org/articles/10.3389/fneur.2021.621392/fullgraft-versus-host diseasecentral nervous systemdiffuse white matter lesionsimmunosuppressionbone marrow transplantation
collection DOAJ
language English
format Article
sources DOAJ
author Mingming Li
Yue Zhang
Yujia Guan
Zunwei Zhang
Hanbing Dong
Yang Zhao
Hui Deng
spellingShingle Mingming Li
Yue Zhang
Yujia Guan
Zunwei Zhang
Hanbing Dong
Yang Zhao
Hui Deng
A Case Report of Central Nervous System Graft-Versus-Host Disease and Literature Review
Frontiers in Neurology
graft-versus-host disease
central nervous system
diffuse white matter lesions
immunosuppression
bone marrow transplantation
author_facet Mingming Li
Yue Zhang
Yujia Guan
Zunwei Zhang
Hanbing Dong
Yang Zhao
Hui Deng
author_sort Mingming Li
title A Case Report of Central Nervous System Graft-Versus-Host Disease and Literature Review
title_short A Case Report of Central Nervous System Graft-Versus-Host Disease and Literature Review
title_full A Case Report of Central Nervous System Graft-Versus-Host Disease and Literature Review
title_fullStr A Case Report of Central Nervous System Graft-Versus-Host Disease and Literature Review
title_full_unstemmed A Case Report of Central Nervous System Graft-Versus-Host Disease and Literature Review
title_sort case report of central nervous system graft-versus-host disease and literature review
publisher Frontiers Media S.A.
series Frontiers in Neurology
issn 1664-2295
publishDate 2021-03-01
description As an adverse immune phenomenon, graft-versus-host disease often occurs after allogeneic hematopoietic stem cell transplantation. The incidence of acute and chronic graft-versus-host disease is about 40–60% and the mortality rate can reach 15%, which is a potentially fatal disease. There are rare GvHD cases involving the central nervous system. We reported a rare case of diffuse white matter changes after haploid bone marrow transplantation, summarizing its clinical manifestations and diagnosis and treatment in conjunction with the literature.
topic graft-versus-host disease
central nervous system
diffuse white matter lesions
immunosuppression
bone marrow transplantation
url https://www.frontiersin.org/articles/10.3389/fneur.2021.621392/full
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