A Case Report of Central Nervous System Graft-Versus-Host Disease and Literature Review

• Main Authors: Mingming Li, Yue Zhang, Yujia Guan, Zunwei Zhang, Hanbing Dong, Yang Zhao, Hui Deng
• Format: Article
• Language: English
• Published: Frontiers Media S.A. 2021-03-01
• Series: Frontiers in Neurology
• Subjects: graft-versus-host disease; central nervous system; diffuse white matter lesions; immunosuppression; bone marrow transplantation
• Online Access: https://www.frontiersin.org/articles/10.3389/fneur.2021.621392/full
• ISSN: 1664-2295

As an adverse immune phenomenon, graft-versus-host disease often occurs after allogeneic hematopoietic stem cell transplantation. The incidence of acute and chronic graft-versus-host disease is about 40–60% and the mortality rate can reach 15%, which is a potentially fatal disease. There are rare GvHD cases involving the central nervous system. We reported a rare case of diffuse white matter changes after haploid bone marrow transplantation, summarizing its clinical manifestations and diagnosis and treatment in conjunction with the literature.