Demethylation by 5-aza-2'-deoxycytidine in colorectal cancer cells targets genomic DNA whilst promoter CpG island methylation persists

Demethylation by 5-aza-2'-deoxycytidine in colorectal cancer cells targets genomic DNA whilst promoter CpG island methylation persists

<p>Abstract</p> <p>Background</p> <p>DNA methylation and histone acetylation are epigenetic modifications that act as regulators of gene expression. Aberrant epigenetic gene silencing in tumours is a frequent event, yet the factors which dictate which genes are targeted...

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Bibliographic Details
Main Authors:	Kim Kyu-Tae, Mossman David, Scott Rodney J
Format:	Article
Language:	English
Published:	BMC 2010-07-01
Series:	BMC Cancer
Online Access:	http://www.biomedcentral.com/1471-2407/10/366

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