Forced Exercise-Induced Flushing of Tail Skin in Ovariectomized Mice, as a New Experimental Model of Menopausal Hot Flushes

Forced Exercise-Induced Flushing of Tail Skin in Ovariectomized Mice, as a New Experimental Model of Menopausal Hot Flushes

Hot flushes are the most common complaint of menopausal women. In the present study, a new animal model of hot flushes was established. Tail skin temperature was measured with a thermo tracer after mice were subjected to a forced exercise task using a motor driven treadmill. In ovariectomized mice,...

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Main Authors: Hideki Shuto, Atsushi Yamauchi, Munehiko Ikeda, Yoshio Sohda, Ayako Koga, Kohji Tominaga, Takashi Egawa, Yasufumi Kataoka
Format: Article
Language:English
Published: Elsevier 2005-01-01
Series:Journal of Pharmacological Sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861319321875
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spelling doaj-3c271cd9533a4faaaffee992afe786ae2020-11-25T01:20:32ZengElsevierJournal of Pharmacological Sciences1347-86132005-01-01983323326Forced Exercise-Induced Flushing of Tail Skin in Ovariectomized Mice, as a New Experimental Model of Menopausal Hot FlushesHideki Shuto0Atsushi Yamauchi1Munehiko Ikeda2Yoshio Sohda3Ayako Koga4Kohji Tominaga5Takashi Egawa6Yasufumi Kataoka7Department of Pharmaceutical Care and Health Sciences, Faculty of Pharmaceutical Sciences, Fukuoka University, 8-19-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, JapanDepartment of Pharmaceutical Care and Health Sciences, Faculty of Pharmaceutical Sciences, Fukuoka University, 8-19-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, JapanDepartment of Pharmaceutical Care and Health Sciences, Faculty of Pharmaceutical Sciences, Fukuoka University, 8-19-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, JapanDepartment of Pharmaceutical Care and Health Sciences, Faculty of Pharmaceutical Sciences, Fukuoka University, 8-19-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, JapanDepartment of Pharmaceutical Care and Health Sciences, Faculty of Pharmaceutical Sciences, Fukuoka University, 8-19-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, JapanDepartment of Pharmaceutical Care and Health Sciences, Faculty of Pharmaceutical Sciences, Fukuoka University, 8-19-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, JapanDepartment of Pharmaceutical Care and Health Sciences, Faculty of Pharmaceutical Sciences, Fukuoka University, 8-19-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, JapanDepartment of Pharmaceutical Care and Health Sciences, Faculty of Pharmaceutical Sciences, Fukuoka University, 8-19-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan; Corresponding author. FAX: +81-92-862-2696 E-mail: ykataoka@cis.fukuoka-u.ac.jpHot flushes are the most common complaint of menopausal women. In the present study, a new animal model of hot flushes was established. Tail skin temperature was measured with a thermo tracer after mice were subjected to a forced exercise task using a motor driven treadmill. In ovariectomized mice, forced exercise for 10 min was most effective in increasing tail skin temperature over that of sham-operated mice. This elevation was blocked by estradiol replacement (1 mg/kg per week for 3 weeks), suggesting that our model simulates menopausal hot flushes. Keywords:: ovariectomy, forced exercise, menopausal flushinghttp://www.sciencedirect.com/science/article/pii/S1347861319321875
collection DOAJ
language English
format Article
sources DOAJ
author Hideki Shuto
Atsushi Yamauchi
Munehiko Ikeda
Yoshio Sohda
Ayako Koga
Kohji Tominaga
Takashi Egawa
Yasufumi Kataoka
spellingShingle Hideki Shuto
Atsushi Yamauchi
Munehiko Ikeda
Yoshio Sohda
Ayako Koga
Kohji Tominaga
Takashi Egawa
Yasufumi Kataoka
Forced Exercise-Induced Flushing of Tail Skin in Ovariectomized Mice, as a New Experimental Model of Menopausal Hot Flushes
Journal of Pharmacological Sciences
author_facet Hideki Shuto
Atsushi Yamauchi
Munehiko Ikeda
Yoshio Sohda
Ayako Koga
Kohji Tominaga
Takashi Egawa
Yasufumi Kataoka
author_sort Hideki Shuto
title Forced Exercise-Induced Flushing of Tail Skin in Ovariectomized Mice, as a New Experimental Model of Menopausal Hot Flushes
title_short Forced Exercise-Induced Flushing of Tail Skin in Ovariectomized Mice, as a New Experimental Model of Menopausal Hot Flushes
title_full Forced Exercise-Induced Flushing of Tail Skin in Ovariectomized Mice, as a New Experimental Model of Menopausal Hot Flushes
title_fullStr Forced Exercise-Induced Flushing of Tail Skin in Ovariectomized Mice, as a New Experimental Model of Menopausal Hot Flushes
title_full_unstemmed Forced Exercise-Induced Flushing of Tail Skin in Ovariectomized Mice, as a New Experimental Model of Menopausal Hot Flushes
title_sort forced exercise-induced flushing of tail skin in ovariectomized mice, as a new experimental model of menopausal hot flushes
publisher Elsevier
series Journal of Pharmacological Sciences
issn 1347-8613
publishDate 2005-01-01
description Hot flushes are the most common complaint of menopausal women. In the present study, a new animal model of hot flushes was established. Tail skin temperature was measured with a thermo tracer after mice were subjected to a forced exercise task using a motor driven treadmill. In ovariectomized mice, forced exercise for 10 min was most effective in increasing tail skin temperature over that of sham-operated mice. This elevation was blocked by estradiol replacement (1 mg/kg per week for 3 weeks), suggesting that our model simulates menopausal hot flushes. Keywords:: ovariectomy, forced exercise, menopausal flushing
url http://www.sciencedirect.com/science/article/pii/S1347861319321875
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