CISD2 Attenuates Inflammation and Regulates Microglia Polarization in EOC Microglial Cells—As a Potential Therapeutic Target for Neurodegenerative Dementia

CISD2 Attenuates Inflammation and Regulates Microglia Polarization in EOC Microglial Cells—As a Potential Therapeutic Target for Neurodegenerative Dementia

Background: Accumulating evidence has demonstrated a significant association between microglia-driven inflammation in the brain and neurodegenerative dementia. We previously showed a significant decline in CISD2 expression in mice models with advanced age. Moreover, we observed that the knockdown of...

Full description

Bibliographic Details
Main Author:	Muh-Shi Lin
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2020-08-01
Series:	Frontiers in Aging Neuroscience
Subjects:	CISD2 M1/M2 microglia polarization anti-inflammatory effects aging neurodegenerative disease and dementia
Online Access:	https://www.frontiersin.org/article/10.3389/fnagi.2020.00260/full

Similar Items

Protective Effects of CISD2 and Influence of Curcumin on CISD2 Expression in Aged Animals and Inflammatory Cell Model
by: Chai-Ching Lin, et al.
Published: (2019-03-01)

The NFκB Antagonist CDGSH Iron-Sulfur Domain 2 Is a Promising Target for the Treatment of Neurodegenerative Diseases
by: Woon-Man Kung, et al.
Published: (2021-01-01)

Editorial: Microglial Polarization in the Pathogenesis and Therapeutics of Neurodegenerative Diseases
by: Yu Tang
Published: (2018-05-01)

Beneficial Impacts of Alpha-Eleostearic Acid from Wild Bitter Melon and Curcumin on Promotion of CDGSH Iron-Sulfur Domain 2: Therapeutic Roles in CNS Injuries and Diseases
by: Woon-Man Kung, et al.
Published: (2021-03-01)

Microglial Polarization in the Pathogenesis and Therapeutics of Neurodegenerative Diseases
Published: (2018)

Cryogen spray cooling mitigates inflammation and injury-induced CISD2 decline in rat spinal cord hemisection model
by: Woon-Man Kung, et al.
Published: (2020-12-01)

Intracellular targeting of Cisd2/Miner1 to the endoplasmic reticulum
by: Claudie Bian, et al.
Published: (2021-09-01)

Astrocytes Stimulate Microglial Proliferation and M2 Polarization In Vitro through Crosstalk between Astrocytes and Microglia
by: Sumin Kim, et al.
Published: (2021-08-01)

A donor splice site mutation in CISD2 generates multiple truncated, non-functional isoforms in Wolfram syndrome type 2 patients
by: Monica Cattaneo, et al.
Published: (2017-12-01)

Sequence variants of the aging gene CISD2 and the risk for Alzheimer's disease
by: Ching-Jow Hsieh, et al.
Published: (2015-07-01)

Exercise and the Cisd2 Prolongevity Gene: Two Promising Strategies to Delay the Aging of Skeletal Muscle
by: Yuan-Chi Teng, et al.
Published: (2020-11-01)

Rutin pretreatment promotes microglial M1 to M2 phenotype polarization
by: Guang-Ping Lang, et al.
Published: (2021-01-01)

CISD2 Promotes Resistance to Sorafenib-Induced Ferroptosis by Regulating Autophagy in Hepatocellular Carcinoma
by: Bowen Li, et al.
Published: (2021-08-01)

Mer regulates microglial/macrophage M1/M2 polarization and alleviates neuroinflammation following traumatic brain injury
by: Haijian Wu, et al.
Published: (2021-01-01)

Cisd2 Preserves the Youthful Pattern of the Liver Proteome during Natural Aging of Mice
by: Chen-Hua Huang, et al.
Published: (2021-09-01)

CISD2 plays a role in age-related diseases and cancer
by: Hai-Yang Liao, et al.
Published: (2021-06-01)

Isovitexin-Mediated Regulation of Microglial Polarization in Lipopolysaccharide-Induced Neuroinflammation via Activation of the CaMKKβ/AMPK-PGC-1α Signaling Axis
by: Bingrun Liu, et al.
Published: (2019-11-01)

Dynorphin activation of kappa opioid receptor promotes microglial polarization toward M2 phenotype via TLR4/NF-κB pathway
by: Lin Liu, et al.
Published: (2020-03-01)

Corrigendum: Isovitexin-Mediated Regulation of Microglial Polarization in Lipopolysaccharide-Induced Neuroinflammation via Activation of the CaMKKβ/AMPK-PGC-1α Signaling Axis
by: Bingrun Liu, et al.
Published: (2020-01-01)

Ontogeny and Polarization of Macrophages in Inflammation: Blood monocytes versus tissue macrophages.
by: Adwitia eDey, et al.
Published: (2015-01-01)

Downregulation of CISD2 Has Prognostic Value in Non-Small Cell Lung Cancer and Inhibits the Tumorigenesis by Inducing Mitochondrial Dysfunction
by: Fangchun Shao, et al.
Published: (2021-02-01)

Mitochondria and Calcium Homeostasis: Cisd2 as a Big Player in Cardiac Ageing
by: Chi-Hsiao Yeh, et al.
Published: (2020-12-01)

Ultrarapid Inflammation of the Olfactory Bulb After Spinal Cord Injury: Protective Effects of the Granulocyte Colony-Stimulating Factor on Early Neurodegeneration in the Brain
by: Muh-Shi Lin, et al.
Published: (2021-06-01)

Effects of Betaine on LPS-Stimulated Activation of Microglial M1/M2 Phenotypes by Suppressing TLR4/NF-κB Pathways in N9 Cells
by: Hui Shi, et al.
Published: (2019-01-01)

Saponins from Panax japonicus attenuate cognitive impairment in ageing rats through regulating microglial polarisation and autophagy
by: Xue-Jiao Pi, et al.
Published: (2021-01-01)

Intranasal Delivery of RGD-Containing Osteopontin Heptamer Peptide Confers Neuroprotection in the Ischemic Brain and Augments Microglia M2 Polarization
by: Dashdulam Davaanyam, et al.
Published: (2021-09-01)

The plasticity of primary microglia and their multifaceted effects on endogenous neural stem cells in vitro and in vivo
by: Sabine Ulrike Vay, et al.
Published: (2018-08-01)

Microglial Exosomes in Neurodegenerative Disease
by: Min Guo, et al.
Published: (2021-05-01)

New insight into curcumin-based therapy in spinal cord injuries: CISD2 regulation
by: Chai-Ching Lin, et al.
Published: (2016-01-01)

Exercise training increases expression of mitochondrial translation factors and CISD family
by: Yokokawa, Takumi
Published: (2019)

Endocannabinoid Modulation of Microglial Phenotypes in Neuropathology
by: Mikiei Tanaka, et al.
Published: (2020-02-01)

Camptothecin Regulates Microglia Polarization and Exerts Neuroprotective Effects via Activating AKT/Nrf2/HO-1 and Inhibiting NF-κB Pathways In Vivo and In Vitro
by: Dewei He, et al.
Published: (2021-04-01)

Microglial Activation in the Pathogenesis of Huntington’s Disease
by: Hui-Ming Yang, et al.
Published: (2017-06-01)

Cisd2 Protects the Liver from Oxidative Stress and Ameliorates Western Diet-Induced Nonalcoholic Fatty Liver Disease
by: Yi-Long Huang, et al.
Published: (2021-04-01)

Imaging of microglia in patients with neurodegenerative disorders
by: Marios ePolitis, et al.
Published: (2012-05-01)

Are resting microglia more M2?
by: Jonathan D. Cherry, et al.
Published: (2014-11-01)

Progressive subcortical gliosis: neurodegenerative dementia should not be ignored
by: Feng FENG, et al.
Published: (2017-08-01)

L-Cysteine-Derived H2S Promotes Microglia M2 Polarization via Activation of the AMPK Pathway in Hypoxia-Ischemic Neonatal Mice
by: Xin Zhou, et al.
Published: (2019-03-01)

Lycium barbarum extract promotes M2 polarization and reduces oligomeric amyloid-β-induced inflammatory reactions in microglial cells
by: Zhong-Qing Sun, et al.
Published: (2022-01-01)

Microglia and Monocytes/Macrophages Polarization Reveal Novel Therapeutic Mechanism against Stroke
by: Masato Kanazawa, et al.
Published: (2017-10-01)