NLRP3, NLRP12, and IFI16 Inflammasomes Induction and Caspase-1 Activation Triggered by Virulent HSV-1 Strains Are Associated With Severe Corneal Inflammatory Herpetic Disease

NLRP3, NLRP12, and IFI16 Inflammasomes Induction and Caspase-1 Activation Triggered by Virulent HSV-1 Strains Are Associated With Severe Corneal Inflammatory Herpetic Disease

The crosstalk between the host's inflammasome system and the invading virulent/less-virulent viruses determines the outcome of the ensuing inflammatory response. An appropriate activation of inflammasomes triggers antiviral inflammatory responses that clear the virus and heal the inflamed tissu...

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Bibliographic Details
Main Authors: Pierre-Gregoire Coulon, Nisha Dhanushkodi, Swayam Prakash, Ruchi Srivastava, Soumyabrata Roy, Nuha I. Alomari, Angela M. Nguyen, Wasay R. Warsi, Caitlin Ye, Edgar A. Carlos-Cruz, Uyen T. Mai, Audrey C. Cruel, Keysi M. Ekmekciyan, Eric Pearlman, Lbachir BenMohamed
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Immunology
Subjects:
inflammasome
NLRP3
NLRP12
IFI16
HSV-1
IL-1β
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01631/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.01631/full

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