Continuous hypoxic culturing of human embryonic stem cells enhances SSEA-3 and MYC levels.

Continuous hypoxic culturing of human embryonic stem cells enhances SSEA-3 and MYC levels.

Low oxygen tension (hypoxia) contributes critically to pluripotency of human embryonic stem cells (hESCs) by preventing spontaneous differentiation and supporting self-renewal. However, it is not well understood how hESCs respond to reduced oxygen availability and what are the molecular mechanisms m...

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Bibliographic Details
Main Authors: Elisa Närvä, Juha-Pekka Pursiheimo, Asta Laiho, Nelly Rahkonen, Maheswara Reddy Emani, Miro Viitala, Kirsti Laurila, Roosa Sahla, Riikka Lund, Harri Lähdesmäki, Panu Jaakkola, Riitta Lahesmaa
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3827269?pdf=render

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