Resistance Analyses of HCV NS3/4A Protease and NS5B Polymerase from Clinical Studies of Deleobuvir and Faldaprevir.

Resistance Analyses of HCV NS3/4A Protease and NS5B Polymerase from Clinical Studies of Deleobuvir and Faldaprevir.

BACKGROUND & AIM:The resistance profile of anti-hepatitis C virus (HCV) agents used in combination is important to guide optimal treatment regimens. We evaluated baseline and treatment-emergent NS3/4A and NS5B amino-acid variants among HCV genotype (GT)-1a and -1b-infected patients treated with...

Full description

Bibliographic Details
Main Authors:	Kristi L Berger, Christoph Sarrazin, David R Nelson, Joseph Scherer, Nanshi Sha, Martin Marquis, Alexandra Côté-Martin, Richard Vinisko, Jerry O Stern, Federico J Mensa, George Kukolj
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2016-01-01
Series:	PLoS ONE
Online Access:	http://europepmc.org/articles/PMC4975400?pdf=render

Similar Items

ITPA Genotypes Predict Anemia but Do Not Affect Virological Response with Interferon-Free Faldaprevir, Deleobuvir, and Ribavirin for HCV Infection.
by: Tarik Asselah, et al.
Published: (2015-01-01)

HCVerso1 and 2: faldaprevir with deleobuvir (BI 207127) and ribavirin for treatment-naïve patients with chronic hepatitis C virus genotype-1b infection
by: Sarrazin C, et al.
Published: (2016-11-01)

HCVerso3: An Open-Label, Phase IIb Study of Faldaprevir and Deleobuvir with Ribavirin in Hepatitis C Virus Genotype-1b-Infected Patients with Cirrhosis and Moderate Hepatic Impairment.
by: Christoph Sarrazin, et al.
Published: (2016-01-01)

Synthetic bulky NS4A peptide variants bind to and inhibit HCV NS3 protease
by: Moustafa E. El-Araby, et al.
Published: (2020-07-01)

A conserved NS3 surface patch orchestrates NS2 protease stimulation, NS5A hyperphosphorylation and HCV genome replication.
by: Olaf Isken, et al.
Published: (2015-03-01)

Establishment of Assay Systems for HCV NS3 Protease in Vivo
by: Li, Chi-Hui, et al.
Published: (2001)

Correction: A Conserved NS3 Surface Patch Orchestrates NS2 Protease Stimulation, NS5A Hyperphosphorylation and HCV Genome Replication.
by: Olaf Isken, et al.
Published: (2016-01-01)

Classification of HCV NS5B Polymerase Inhibitors Using Support Vector Machine
by: Changyuan Yu, et al.
Published: (2012-03-01)

The role of NS3 in the replication of HCV RNA
by: Eisa, Zaki
Published: (2005)

Faldaprevir for the Treatment of Hepatitis C
by: Tatsuo Kanda, et al.
Published: (2015-03-01)

Biochemical characteristics of Powassan virus NS3 and analysis of antibody-based inhibitors of HCV NS3
by: Gallivan, John-Paul
Published: (2003)

Faldaprevir, pegylated interferon, and ribavirin for treatment-naïve HCV genotype-1: pooled analysis of two phase 3 trials
by: Donald M. Jensen, et al.
Published: (2016-05-01)

Searching and Identification of HCV NS3-interacting proteins
by: Sun, Tsai-Shia, et al.

Induction of intrahepatic HCV NS4B, NS5A and NS5B-specific cellular immune responses following peripheral immunization.
by: Krystle A Lang Kuhs, et al.
Published: (2012-01-01)

Inhibition on IFN-β Expression by HCV NS3 and NS5A in HepG2 Cells
by: Dong Jin-ling, et al.
Published: (2013-03-01)

Effects of Different Domains of the HCV NS3- NS4A Protein on Its RNA Helicase Activity
by: Yu- Chieh Lin, et al.
Published: (2002)

Correction: Induction of Intrahepatic HCV NS4B, NS5A and NS5B-Specific Cellular Immune Responses following Peripheral Immunization
by: Krystle A. Lang Kuhs, et al.
Published: (2013-01-01)

Hepatitis C virus core, NS3, NS4B and NS5A are the major immunogenic proteins in humoral immunity in chronic HCV infection
by: Lappalainen Maija, et al.
Published: (2009-06-01)

Correction: Induction of Intrahepatic HCV NS4B, NS5A and NS5B-Specific Cellular Immune Responses following Peripheral Immunization.
by: Krystle A. Lang Kuhs, et al.
Published: (2013-01-01)

Evolution, Enzymaktivität und Struktur-Funktions-Analyse der Norovirus-Enzyme Protease (NS6pro) und Polymerase (NS7pol)
by: Kramer, Dorothea
Published: (2012)

Design and Synthesis of Aspartic and Serine Protease Inhibitors : Targeting the BACE-1 and the HCV NS3 Protease
by: Wångsell, Fredrik
Published: (2009)

Investigation of NS3 Protease Resistance-Associated Variants and Phenotypes for the Prediction of Treatment Response to HCV Triple Therapy.
by: Julia Dietz, et al.
Published: (2016-01-01)

A cell-based assay for RNA synthesis by the HCV polymerase reveals new insights on mechanism of polymerase inhibitors and modulation by NS5A.
by: C T Ranjith-Kumar, et al.
Published: (2011-01-01)

The Future of HCV Therapy: NS4B as an Antiviral Target
by: Hadas Dvory-Sobol, et al.
Published: (2010-11-01)

Study on cellular factors interacting with HCV NS3 protein
by: Zhi-Cheng Li, et al.

The NS4A Cofactor Dependent Enhancement of HCV NS3 Protease Activity Correlates with a 4D Geometrical Measure of the Catalytic Triad Region.
by: Hamzah A Hamad, et al.
Published: (2016-01-01)

Engineered toxins "zymoxins" are activated by the HCV NS3 protease by removal of an inhibitory protein domain.
by: Assaf Shapira, et al.
Published: (2011-01-01)

Metalloprotoporphyrin Inhibition of HCV NS3-4A Protease: Structure–Activity Relationships
by: Hu K, et al.
Published: (2020-02-01)

Hydroxychloroquine Inhibits Zika Virus NS2B-NS3 Protease
by: Ankur Kumar, et al.
Published: (2018-12-01)

Description of new maize hybrids: NS 5073, NS 5120, NS 5021 i NS ALEKSANDRA
by: Stojaković Milisav, et al.
Published: (2011-01-01)

MODIFICATIONS AND FREQUENCY OCCURRENCE OF GESTURES IN NS - NS AND NNS - NS DYADS
by: Juliana Wijaya
Published: (1999-01-01)

The effects if the intra- and inter-molecular interactions betweenthe domains of the HCV NS3 and NS4A on the RNA helicase activity
by: Wan-Fen Kuang, et al.
Published: (2003)

1<i>H</i>-Imidazole-2,5-Dicarboxamides as NS4A Peptidomimetics: Identification of a New Approach to Inhibit HCV-NS3 Protease
by: Abdelsattar M. Omar, et al.
Published: (2020-03-01)

The HCV non-nucleoside inhibitor Tegobuvir utilizes a novel mechanism of action to inhibit NS5B polymerase function.
by: Christy M Hebner, et al.
Published: (2012-01-01)

Cell penetrable humanized-VH/V(H)H that inhibit RNA dependent RNA polymerase (NS5B) of HCV.
by: Kanyarat Thueng-in, et al.
Published: (2012-01-01)

Design, Synthesis and Biological Evaluation of Heterocyclic Compounds with Diketo Acid Bioisosteric Pharmacophores as HCV NS5B Polymerase Inhibitors
by: Ravindra Ramesh Deore, et al.
Published: (2011)

Insight into the drug resistance mechanisms of GS-9669 caused by mutations of HCV NS5B polymerase via molecular simulation
by: Di Han, et al.
Published: (2021-01-01)

Direct binding of ledipasvir to HCV NS5A: mechanism of resistance to an HCV antiviral agent.
by: Hyock Joo Kwon, et al.
Published: (2015-01-01)

Implications of hcv natural genetic diversity on HCV NS5B inhibitor NM283
by: Demetriou Victoria L, et al.
Published: (2010-05-01)

HCV NS3 inhibitors resistance mutations in the telaprevir started Turkish patients with chronic HCV
by: M. Sayan, et al.
Published: (2014-04-01)